ArticlePsychopharmacology2020
The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates.
Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The Influence of Cannabis and Nicotine Co-use on Neuromaturation: A Systematic Review of Adolescent and Young Adult Studies.Biological psychiatry · 2021Pooled it
- Age of onset of nicotine use and severity of nicotine addiction symptoms are associated with hippocampal volume in late adolescents and emerging adults.Frontiers in adolescent medicine · 2025Article
- Substance Use and Social Influence as Risk Factors for Nicotine and Tobacco Product Use in Adolescents and Young Adults who use Electronic Nicotine Delivery Systems.Frontiers in adolescent medicine · 2025Article
- A preliminary investigation of physical and mental health features of cannabis & nicotine co-use among adolescents and young adults by sex.Addictive behaviors · 2024Article
- Investigating sex differences and age of onset in emotion regulation, executive functioning, and cannabis use in adolescents and young adults.Journal of cannabis research · 2024Article
- Neurite Orientation Dispersion and Density Imaging (NODDI) of Brain Microstructure in Adolescent Cannabis and Nicotine Use.Behavioral sciences (Basel, Switzerland) · 2024Article
- The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults.Brain sciences · 2024Article
- The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates.Brain imaging and behavior · 2024Article
- Nicotine use during late adolescence and young adulthood is associated with changes in hippocampal volume and memory performance.Frontiers in neuroscience · 2024Article
- First Used Nicotine/Cannabis Product and Associated Outcomes in Late Adolescents.Substance use & misuse · 2024Article
- Socio-demographic Correlates of Electronic Cigarette and Cannabis Co-use Among Naïve and Tobacco Adolescent Users.Journal of prevention (2022) · 2023Article
- Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance.Brain sciences · 2022Article
- The Effects of Nicotine and Cannabis Co-Use During Late Adolescence on White Matter Fiber Tract Microstructure.Journal of studies on alcohol and drugs · 2022Article
- Tobacco and Nervous System Development and Function-New Findings 2015-2020.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
rationaleCo-use of cannabis and nicotine is common among adolescents/young adults and is associated with poorer psychological and physical outcomes, compared with single substance use. Little is known about the impact of co-use on the developing brain.
objectivesPreliminary investigation of the effects of nicotine on white matter (WM) cerebral blood flow (CBF) in adolescents/young adults and its potential moderation by cannabis use.
methodsAdolescent/young adult (16-22 years old) nicotine and tobacco product users (NTP; N = 37) and non-nicotine users (non-NTP; N = 26) underwent a neuroimaging session comprised of anatomical, optimized pseudo-continuous arterial spin labeling, and diffusion tensor imaging scans. Groups were compared on whole-brain WM CBF estimates and their relation to past-year cannabis use. Follow-up analyses assessed correlations between identified CBF clusters and corresponding fractional anisotropy (FA) values.
resultsGroup by cannabis effects were observed in five clusters (voxel-wise alpha < 0.001, cluster-wise alpha < 0.05; ≥ 11 contiguous voxels): non-NTP exhibited positive correlations between CBF and cannabis use in all clusters, whereas no significant relationships were observed for NTP. Greater CBF extracted from one cluster (including portions of right superior longitudinal fasciculus) was associated with reduced FA for non-NTP group only.
conclusionsThis is the first investigation of WM health as indexed by CBF, and its association with FA, in adolescents/young adults with nicotine and/or cannabis use. Results suggest that cannabis use by itself may be related to increased CBF in WM fiber tracts demonstrating poorer structural intergrity, yet the occurrence of even infrequent NTP use (greater than once per month) appears to diminish this relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.