ArticleNeuroradiology2021
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols.
Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T.Magnetic resonance in medicine · 2026Article
- microGLYMPH: a conceptual translational roadmap for microdialysis‑based assessment of CSF-interstitial solute exchange in acquired brain injury.Critical care (London, England) · 2026Review
- Glymphatic System Visualized With Intrathecal Gadoterate Meglumine Administered via External Ventricular Drain.Cureus · 2026Article
- Human brain MRI data of intrathecally injected tracer evolution over 72 hours for data-integrated simulations.Scientific data · 2026Article
- Do enlarged white matter perivascular spaces reflect brain clearance dysfunction? Insights from intrathecal contrast-enhanced MRI.Neuroradiology · 2026Article
- Review
- Altered brain fluid dynamics in spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2025Observational
- Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024Article
- The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases.Brain sciences · 2024Review
- Neurosurgery and the glymphatic system.Acta neurochirurgica · 2024Review
- Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans.Cellular and molecular life sciences : CMLS · 2024Review
- Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.Journal of magnetic resonance imaging : JMRI · 2024Review
- Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases.BMC neurology · 2023Article
- Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol.Neuroradiology · 2023Article
- Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging.Korean journal of radiology · 2023Article
- Prospective Safety Study of Intrathecal Gadobutrol in Different Doses.AJNR. American journal of neuroradiology · 2023Article
- Cerebrospinal Fluid Production and Absorption and Ventricular Enlargement Mechanisms in Hydrocephalus.Neurologia medico-chirurgica · 2023Article
- Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation.Brain communications · 2023Article
- Encephalopathy after unintentional intrathecal gadolinium: A letter to the editor.Interventional pain medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMagnetic resonance imaging (MRI) contrast agents have been used off-label for diagnosis of cerebrospinal fluid (CSF) leaks and lately also for assessment of the glymphatic system and meningeal lymphatic drainage. The purpose of this study was to further evaluate the short- and long-term safety profile of intrathecal MRI contrast agents.
methodsIn this prospective study, we compared the safety profile of different administration protocols of intrathecal gadobutrol (Gadovist
resultsAmong the 149 patients, no serious adverse events were seen in patients without history of prior adverse events. The combination of gadobutrol with iodixanol did not increase the occurrence of non-serious adverse events after days 1-3. Intrathecal gadobutrol in a dose of 0.25 mmol caused less severity of nausea, as compared with the dose of 0.5 mmol. The clinical diagnosis was the major determinant for occurrence of non-serious adverse events after intrathecal gadobutrol.
conclusionThis prospective study showed that intrathecal administration of gadobutrol in a dose of 0.5 mmol is safe. Non-serious adverse events were to a lesser degree affected by the administration protocols, though preliminary data are given that side effects of intrathecal gadobutrol are dose-dependent.
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