Evidence map›Paper›PMID 32803273›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2020

Human carnosinase 1 overexpression aggravates diabetes and renal impairment in BTBR

Jiedong Qiu, Thomas Albrecht, Shiqi Zhang, Sibylle J Hauske, Angelica Rodriguez-Niño, Xinmiao Zhang, Darya Nosan, Diego O Pastene, Carsten Sticht, Carolina Delatorre and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. CNDP1 (CTG)Scientific reports · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Histidine-Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Jiedong Qiu5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany. jiedong.qiu@medma.uni-heidelberg.de.ORCID 0000-0002-9835-8398
Thomas Albrecht5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Shiqi Zhang5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Sibylle J Hauske5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Angelica Rodriguez-Niño5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Xinmiao Zhang5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Darya Nosan5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Diego O Pastene5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Carsten StichtCentral Medical Research Facility ZMF, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Carolina DelatorreCentral Medical Research Facility ZMF, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands.
Stefan PorubskyInstitute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Bernhard K Krämer5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Benito A Yard5th Medical Department, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Heidelberg University · DEUniversity Medical Center Groningen · NLAnhui Medical University · CNJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the influence of serum carnosinase (CN1) on the course of diabetic kidney disease (DKD).

methodshCN1 transgenic (TG) mice were generated in a BTBR

resultshCN1 was detected in the serum and urine of mice from two different hCN1 TG lines. The transgene was expressed in the liver but not in the kidney. High CN1 expression was associated with low plasma and renal carnosine concentrations, even after oral carnosine supplementation. Obese hCN1 transgenic BTBR

conclusionsOur data support a role for serum carnosinase 1 in the progression of DKD. Whether this is mainly attributed to the changes in renal carnosine concentrations warrants further studies. KEY MESSAGES: Increased carnosinase 1 (CN1) is associated with diabetic kidney disease (DKD). BTBR

Indexed as

Diabetes Mellitus, ExperimentalGene ExpressionAnimalsBiomarkersComputational BiologyDiabetic NephropathiesDipeptidasesDisease Models, AnimalGene Expression ProfilingHumansImmunohistochemistryKidneyMiceMice, ObeseMice, TransgenicBiomarkersCNDP1 protein, humanDipeptidasesAntioxidantsCarnosineDiabetic nephropathyGene expression profilingTransgenic mice

Identifiers

PMID32803273
PMCPMC7447680
OpenAlexW3049272539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.