ArticleNAR cancer2020
Pan-cancer proteogenomic analysis reveals long and circular noncoding RNAs encoding peptides.
Article in NAR cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation.Journal of advanced research · 2026Review
- Integration of Short- and Long-Read RNA Sequencing Enables the Discovery of Circular RNAs.Cancer research · 2026Article
- Functional mechanisms of circular RNA‑encoded peptides and future research strategies and directions in nasopharyngeal carcinoma (Review).International journal of oncology · 2025Review
- SORFPP: Enhancing rich sequence-driven information to identify SEPs based on fused framework on validation datasets.PloS one · 2025Article
- Improving deep models of protein-coding potential with a Fourier-transform architecture and machine translation task.PLoS computational biology · 2023Article
- INTEGRATE-Circ and INTEGRATE-Vis: unbiased detection and visualization of fusion-derived circular RNA.Bioinformatics (Oxford, England) · 2023Article
- CrypticProteinDB: an integrated database of proteome and immunopeptidome derived non-canonical cancer proteins.NAR cancer · 2023Article
- Ranking Breast Cancer Drugs and Biomarkers Identification Using Machine Learning and Pharmacogenomics.ACS pharmacology & translational science · 2023Article
- Pan-Cancer Analysis Reveals Recurrent BCAR4 Gene Fusions across Solid Tumors.Molecular cancer research : MCR · 2022Article
- TransLnc: a comprehensive resource for translatable lncRNAs extends immunopeptidome.Nucleic acids research · 2022Article
- Long, Noncoding RNA Dysregulation in Glioblastoma.Cancers · 2021Review
- Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy.Frontiers in pharmacology · 2021Review
- Protein-gene Expression Nexus: Comprehensive characterization of human cancer cell lines with proteogenomic analysis.Computational and structural biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies show that annotated long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) encode for stable, functional peptides that contribute to human development and disease. To systematically discover lncRNAs and circRNAs encoding peptides, we performed a comprehensive integrative analysis of mass spectrometry-based proteomic and transcriptomic sequencing data from >900 patients across nine cancer types. This enabled us to identify 19,871 novel peptides derived from 8,903 lncRNAs. Further, we exploited open reading frames overlapping the backspliced region of circRNAs to identify 3,238 peptides that are uniquely derived from 2,834 circRNAs and not their corresponding linear RNAs. Collectively, our pan-cancer proteogenomic analysis will serve as a resource for evaluating the coding potential of lncRNAs and circRNAs that could aid future mechanistic studies exploring their function in cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.