Evidence map›Paper›PMID 32803099›Full record

ArticleJB & JS open access

Association Between Preoperative Radiographic Severity of Osteoarthritis and Patient-Reported Outcomes of Total Knee Replacement.

Jeffrey K Lange, Heidi Y Yang, Jamie E Collins, Elena Losina, Jeffrey N Katz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JB & JS open access. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jeffrey K LangeDepartment of Orthopedic Surgery (J.K.L., H.Y.Y., J.E.C., E.L., and J.N.K.), Division of Rheumatology, Immunology, and Allergy (J.N.K.), and The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) (H.Y.Y., J.E.C., E.L., and J.N.K.), Brigham and Women's Hospital, Boston, Massachusetts.
Heidi Y YangDepartment of Orthopedic Surgery (J.K.L., H.Y.Y., J.E.C., E.L., and J.N.K.), Division of Rheumatology, Immunology, and Allergy (J.N.K.), and The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) (H.Y.Y., J.E.C., E.L., and J.N.K.), Brigham and Women's Hospital, Boston, Massachusetts.
Jamie E CollinsDepartment of Orthopedic Surgery (J.K.L., H.Y.Y., J.E.C., E.L., and J.N.K.), Division of Rheumatology, Immunology, and Allergy (J.N.K.), and The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) (H.Y.Y., J.E.C., E.L., and J.N.K.), Brigham and Women's Hospital, Boston, Massachusetts.
Elena LosinaDepartment of Orthopedic Surgery (J.K.L., H.Y.Y., J.E.C., E.L., and J.N.K.), Division of Rheumatology, Immunology, and Allergy (J.N.K.), and The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) (H.Y.Y., J.E.C., E.L., and J.N.K.), Brigham and Women's Hospital, Boston, Massachusetts.
Jeffrey N KatzDepartment of Orthopedic Surgery (J.K.L., H.Y.Y., J.E.C., E.L., and J.N.K.), Division of Rheumatology, Immunology, and Allergy (J.N.K.), and The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) (H.Y.Y., J.E.C., E.L., and J.N.K.), Brigham and Women's Hospital, Boston, Massachusetts.
Brigham and Women's Hospital · USBoston University · US

Funding

Trial of risk mangement for prevention of accelerated atherosclerosis in SLEP60AR047782 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2001 to 2016
$18.8M
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
NIAMS NIH HHS K24 AR057827NIAMS NIH HHS P30 AR072577NIAMS NIH HHS P60 AR047782
6 · The paper itself

Abstract

backgroundThe goal of this study was to investigate the association between preoperative radiographic severity of knee osteoarthritis (OA) and patient-reported outcomes following total knee replacement.

methodsWe used data from a prospective cohort study of individuals who underwent total knee replacement at a high-volume medical center. Patient-reported outcomes included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score and the Knee injury and Osteoarthritis Outcome Score (KOOS) activities of daily living (ADL) subscore, assessed preoperatively and 2 years postoperatively. We measured preoperative radiographic OA severity using the Osteoarthritis Research Society International (OARSI) Atlas score, dichotomized at the median. We assessed the association between radiographic OA severity and postoperative patient-reported outcomes in bivariate analyses and in multivariable linear regression, with adjustment for age, sex, body mass index, and comorbidity score.

resultsThe analytic cohort included 240 patients with a mean age at surgery of 66.6 years (standard deviation, 8 years); 61% were female. The median total OARSI radiographic severity score was 10 (range, 3 to 17). The cohort improved substantially at 2 years following total knee replacement, with WOMAC pain and KOOS ADL score improvements on the order of 30 points. We did not observe significant or clinically important differences in pain relief or functional improvement between patients with milder and more severe radiographic OA. Sensitivity analyses using other radiographic assessment measures yielded similar findings.

conclusionsTotal knee replacement offers substantial symptomatic relief and functional improvement regardless of preoperative radiographic OA severity. LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Identifiers

PMID32803099
PMCPMC7386538
OpenAlexW3041162556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.