ReviewJournal of thoracic disease2020
Gender differences in aortic valve replacement: is surgical aortic valve replacement riskier and transcatheter aortic valve replacement safer in women than in men?
Review in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Gender Disparities after Transcatheter Aortic Valve Replacement with Newer Generation Transcatheter Heart Valves: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2023Pooled it
- The "Cairo Accord"- towards the eradication of RHD: revisited (2026).Frontiers in cardiovascular medicine · 2026Review
- Determinants of the quality of life of care partners in the context of surgical cardiovascular interventions: A qualitative study.PloS one · 2026Article
- Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement.GeroScience · 2025Article
- Sex-related differences in patient characteristics, practice patterns and outcomes after bioprosthetic and mechanical aortic valve replacement.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Sex-Related Differences in the Pathophysiology, Cardiac Imaging, and Clinical Outcomes of Aortic Stenosis: A Narrative Review.Journal of clinical medicine · 2024Review
- Sex-related disparities in aortic stenosis from disease awareness to treatment: a state-of-the-art review.Journal of thoracic disease · 2024Review
- Sex-related differences among patients undergoing surgical aortic valve replacement-a propensity score matched study.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Perioperative Management of Valvular Heart Disease in Patients Undergoing Non-Cardiac Surgery.Journal of clinical medicine · 2024Review
- The influence of gender on outcomes following transcatheter aortic valve implantation.Frontiers in cardiovascular medicine · 2024Article
- Improved Early Outcomes in Women Undergoing Aortic Valve Interventions.Journal of clinical medicine · 2023Article
- The Quality of Life in Patients With Valve Prosthesis After Undergoing Surgery for Valvular Heart Diseases.Cureus · 2023Article
- Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine.American heart journal plus : cardiology research and practice · 2022Article
- Sex difference and outcome trends following transcatheter aortic valve replacement.Frontiers in cardiovascular medicine · 2022Article
- IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe.Open heart · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aortic stenosis (AS) is a progressive and degenerative disease that necessitates valve replacement through either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). Various studies have shown that, unlike for TAVR, SAVR is associated with an elevated risk for women as compared to men. The aim of this review is to better understand the risks and their possible causes, associated with the use of both TAVR and SAVR in female patients. Our systematic review included studies published between 2012 and 2020, identified through specific searches of PubMed. Compatibility of publications, determined by the use of pre-defined inclusion/exclusion criteria, resulted in 15 articles being used in our review. Overall, more men than women undergo SAVR, but our findings confirmed that SAVR is associated with worse outcomes in women in the short-term. Reasons for a higher 30-day mortality post-SAVR in women include an increased age, higher in-hospital mortality and, possibly baseline comorbidities and anatomical differences. There was no difference observed in 30-day mortality between men and women undergoing TAVR. Female patients appear to have a better longer-term survival post-TAVR than their male counterparts. Understanding the reasons why women have worse outcomes post-SAVR is essential for ensuring appropriate treatment selection for patients with AS, as well as for achieving the best possible long-term and safety outcomes for these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.