Evidence map›Paper›PMID 32802324›Full record

ReviewAnnals of medicine and surgery (2012)2020

Closure of the appendiceal stump in laparoscopic appendectomy: A systematic review of the literature.

N Makaram, S R Knight, A Ibrahim, P Patil, M S J Wilson

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine and surgery (2012), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07115303 (Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07115303 narecruitingnot on this mapstarted 2025, after this paper: background citation

Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure: A Comparative Study

TypeinterventionalSponsorSohag UniversityRan2025 to 2026Enrolled80ConditionsAppendicitisArmsLaparoscopic Appendectomy with application of clips for stump closure, Laparoscopic Appendectomy with ligature for stump closure
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Acute appendicitis and its treatment: a historical overview.International journal of colorectal disease · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. The use of the extracorporeally prepared hand-made endo-loop technique in laparoscopic appendectomy.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023
    Article
  19. Article
  20. Laparoscopic appendectomy, stump closure and endoloops: A meta-analysis.World journal of gastrointestinal surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

N MakaramDepartment of General Surgery, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
S R KnightUsher Institute, University of Edinburgh, Edinburgh, EH16 4XU, UK.
A IbrahimDepartment of General Surgery, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
P PatilDepartment of General Surgery, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
M S J WilsonDepartment of General Surgery, Forth Valley Royal Hospital, Larbert, FK5 4WR, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClosure of the appendiceal stump is a key step performed during laparoscopic appendicectomy. Inadequate management of the appendiceal stump has the potential to cause significant morbidity. Several methods of stump closure have been described, however high-level evidence is limited. We performed a systematic review evaluating clinical outcomes and quality of the evidence for the methods of appendiceal stump closure.

methodsA systematic literature search was performed using Medline, Embase, Cochrane Database and Google Scholar to identify studies comparing appendiceal stump closure methods in laparoscopic appendectomy for acute appendicitis from inception to October 2019. Data regarding operative duration, peri-operative complications, length of stay and costs were collated from all included studies.

resultsFrom 160 identified studies, 19 met the inclusion criteria. Endoloops and endoclips provide equivalent clinical outcomes at lower cost, while operative duration was shortest with endoclip closure. Endostapler devices have the lowest rate of peri-operative complications (3.56%), however their cost limits their regular use in many healthcare environments. Post-operative complication rate and length of stay were similar for all stump closure methods. Conclusion: Although there are no significant differences in method of stump closure in laparoscopic appendectomy, closure with endoclips provides the shortest operative duration. There is a need for robust and standardized reporting of cost data when comparing stump closure methods, together with higher level evidence in the form of multi-centre randomized controlled trials before firm conclusions can be drawn regarding the optimal method of stump closure.

Indexed as

AppendicectomyAppendicitisEL, EndoloopLA, Laparoscopic AppendicectomyReviewStump closure

Identifiers

PMID32802324
PMCPMC7419254

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.