Evidence map›Paper›PMID 32802201›Full record

ArticleTheranostics2020

Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway.

Lu Chen, Yanping Wang, Shulin Li, Bangjie Zuo, Xiangyu Zhang, Fengzhen Wang, Dong Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lu ChenDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Yanping WangDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Shulin LiDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Bangjie ZuoDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xiangyu ZhangDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Fengzhen WangDepartment of Pharmaceutics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Dong SunDepartment of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have emerged as ideal cell-based therapeutic candidates for the structural and functional restoration of the diseased kidney. Glial cell line-derived neurotrophic factor (GDNF) has been demonstrated to promote the therapeutic effect of MSCs on ameliorating renal injury. The mechanism may involve the transfer of endogenous molecules via paracrine factors to salvage injured cells, but these factors remain unknown.

Indexed as

Adipose TissueAdultAnimalsCells, CulturedDisease Models, AnimalEndothelial CellsExosomesFemaleFibrosisGlial Cell Line-Derived Neurotrophic FactorHumansHuman Umbilical Vein Endothelial CellsKidneyKidney DiseasesMaleMesenchymal Stem CellsGDNF protein, humanGlial Cell Line-Derived Neurotrophic FactorNitric Oxide Synthase Type IIINOS3 protein, humanSIRT1 protein, humanSirtuin 1Adipose tissue-derived mesenchymal stem cellChronic kidney diseaseExosomeGlial cell line-derived neurotrophic factorPeritubular capillary

Identifiers

PMID32802201
PMCPMC7415791
OpenAlexW3045089985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.