ReviewIranian journal of pharmaceutical research : IJPR2019
Osmolyte-Induced Folding and Stability of Proteins: Concepts and Characterization.
Review in Iranian journal of pharmaceutical research : IJPR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Article
- Consumption of L-Proline as Energy Substrate by Cultured Primary Rat Astrocytes.Neurochemical research · 2025Article
- Exploring the effects of excipients on complex coacervation.Journal of colloid and interface science · 2025Article
- Helix Folding in One Dimension: Effects of Proline Co-Solvent on Free Energy Landscape of Hydrogen Bond Dynamics in Alanine Peptides.Life (Basel, Switzerland) · 2025Article
- Article
- Phenylalanine as an effective stabilizer and aggregation inhibitor of Bacillus amyloliquefaciens alpha-amylase.AMB Express · 2024Article
- Review
- Effects of Proline on Internal Friction in Simulated Folding Dynamics of Several Alanine-Based α-Helical Peptides.The journal of physical chemistry. B · 2024Article
- Taurine, a Naturally Occurring Amino Acid, as a Physical Stability Enhancer of Different Monoclonal Antibodies.The AAPS journal · 2024Article
- Effect of Chemical Chaperones on the Stability of Proteins during Heat- or Freeze-Thaw Stress.International journal of molecular sciences · 2023Article
- Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations of Polysorbates.Pharmaceutics · 2022Review
- The ability of trimethylamine N-oxide to resist pressure induced perturbations to water structure.Communications chemistry · 2022Article
- Acute and Chronic Hyponatremia.Frontiers in medicine · 2021Review
- Antibacterial Albumin-Tannic Acid Coatings for Scaffold-Guided Breast Reconstruction.Frontiers in bioengineering and biotechnology · 2021Article
- Proline Accumulation in Pollen Grains as Potential Target for Improved Yield Stability Under Salt Stress.Frontiers in plant science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well-known that the typical protein's three-dimensional structure is relatively unstable in harsh conditions. A practical approach to maintain the folded state and thus improve the stability and activity of proteins in unusual circumstances is to directly apply stabilizing substances such as osmolytes to the protein-containing solutions. Osmolytes as natural occurring organic molecules typically called "compatible" solutes, based on the concept that they do not perturb cellular components. However, urea and guanidine hydrochloride (GuHCl) as denaturing osmolytes destabilize many macromolecular structures and inhibit functions. Several studies have been so far performed to explain the actual interaction of an osmolyte with a protein. The present review is aimed to achieve a collective knowledge of the progress arise in the field of osmolyte-protein interactions. The following is also an overview of the main techniques to measure protein stability in the presence of osmolytes.
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Registered trials
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