SynthesisNeural plasticity2020
Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor.
Synthesis in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Loss of long-term benefit from VIM-DBS in essential tremor: A secondary analysis of repeated measurements.CNS neuroscience & therapeutics · 2022Pooled it
- Long-term safety and efficacy of intracortical microstimulation in humans.Science translational medicine · 2026Trial
- Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.Neurology · 2023Trial
- The emerging role of high-intensity focused ultrasound (HIFU) as a symptomatic treatment for Parkinson's disease and essential tremor: a narrative review.Arquivos de neuro-psiquiatria · 2026Review
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Decoding pre-movement neural activity from thalamic LFPs for adaptive neurostimulation in tremor patients.Neurocomputing · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Natural disease progression vs. DBS-related worsening in essential tremor.medRxiv : the preprint server for health sciences · 2025Article
- Reply: "Target the Circuit, Not the Brain: Rethinking Essential Tremor Therapy".Movement disorders clinical practice · 2025Article
- Case Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-stroke Pain.Neurology and therapy · 2025Article
- Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.Movement disorders clinical practice · 2025Review
- Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.NPJ Parkinson's disease · 2025Article
- Dissociation between Simple and Complex Speech Motor Tasks within the Bilateral Motor Thalamus.eNeuro · 2025Article
- High-intensity focused ultrasound (HIFU) versus deep brain stimulation (DBS) for refractory tremor: team HIFU.Arquivos de neuro-psiquiatria · 2025Review
- Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A Double-Blind, Randomized, Crossover Study.Journal of clinical medicine · 2024Article
- Managing Lead Fractures in Deep Brain Stimulation for Movement Disorders: A Decade-Long Case Series from a National Neurosurgical Centre.Journal of clinical medicine · 2024Article
- Neuromodulation techniques - From non-invasive brain stimulation to deep brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Management of essential tremor deep brain stimulation-induced side effects.Frontiers in human neuroscience · 2024Review
- Reasons for Hospitalizations and Emergency Department Visits Among Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.Annals of clinical and translational neurology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study was aimed at identifying the potential outcome predictors, comparing the efficacy in patients with different tremor characteristics, and summarizing the adverse effect rates (AERs) of deep brain stimulation on the ventral intermediate nucleus (VIM-DBS) for essential tremor (ET). Methods: An extensive search of articles published to date in 2019 was conducted, and two main aspects were analyzed. Improvement was calculated as a percentage of change in any objective tremor rating scale (TRS) and analyzed by subgroup analyses of patients' tremor characteristics, laterality, and stimulation parameters. Furthermore, the AERs were analyzed as follows: the adverse effects (AEs) were classified as stimulation-related, surgical-related, or device-related effects. A simple regression analysis was used to identify the potential prognostic factors, and a two-sample mean-comparison test was used to verify the statistical significance of the subgroup analyses. Results: Forty-six articles involving 1714 patients were included in the meta-analysis. The pooled improvement in any objective TRS score was 61.3% (95% CI: 0.564-0.660) at the mean follow-up visit (20.0 ± 17.3 months). The midline and extremity symptoms showed consistent improvement ( Conclusion: VIM-DBS is an efficient and safe surgical method in ET, and the efficacy was not affected by the body distribution of tremor, age at surgery, and disease duration. Lower preoperative FTM-TRS scores likely indicate greater improvement, and the effect of VIM-DBS declines over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.