Evidence map›Paper›PMID 32802002›Full record

ArticleJournal of machine learning research : JMLR2020

A Regularization-Based Adaptive Test for High-Dimensional Generalized Linear Models.

Chong Wu, Gongjun Xu, Xiaotong Shen, Wei Pan

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of machine learning research : JMLR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chong WuDepartment of Statistics, Florida State University, FL, USA.
Gongjun XuDepartment of Statistics, University of Michigan, MI, USA.
Xiaotong ShenSchool of Statistics, University of Minnesota, MN, USA.
Wei PanDivision of Biostatistics, University of Minnesota, MN, USA.

Funding

Association analysis of rare variants with sequencing dataR01HL116720 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAN, WEI, WEI, PENG · 2013 to 2020
$3.3M
Discovering causal genes, brain regions and other risk factors for Alzheimer's DiseaseR01AG065636 · NIA · UNIVERSITY OF MINNESOTA · PI PAN, WEI · 2020 to 2024
$3.1M
Powerful Inference and Prediction for Genetic AssociationR01HL105397 · NHLBI · UNIVERSITY OF MINNESOTA · PI PAN, WEI, SHEN, XIAOTONG TOM · 2011 to 2018
$2.9M
New Machine Learning Tools for Biomedical DataR01GM081535 · NIGMS · UNIVERSITY OF MINNESOTA · PI PAN, WEI, SHEN, XIAOTONG TOM · 2007 to 2014
$2.2M
Estimation and Inference of Gene Regulatory NetworksR01GM126002 · NIGMS · UNIVERSITY OF MINNESOTA · PI PAN, WEI, SHEN, XIAOTONG TOM · 2017 to 2020
$1.4M
Statistical Methods for Genomic DataR01GM113250 · NIGMS · UNIVERSITY OF MINNESOTA · PI PAN, WEI · 2014 to 2017
$702k
NHLBI NIH HHS R01 HL105397NHLBI NIH HHS R01 HL116720NIA NIH HHS R01 AG065636NIGMS NIH HHS R01 GM081535NIGMS NIH HHS R01 GM113250NIGMS NIH HHS R01 GM126002
6 · The paper itself

Abstract

In spite of its urgent importance in the era of big data, testing high-dimensional parameters in generalized linear models (GLMs) in the presence of high-dimensional nuisance parameters has been largely under-studied, especially with regard to constructing powerful tests for general (and unknown) alternatives. Most existing tests are powerful only against certain alternatives and may yield incorrect Type I error rates under high-dimensional nuisance parameter situations. In this paper, we propose the adaptive interaction sum of powered score (aiSPU) test in the framework of penalized regression with a non-convex penalty, called truncated Lasso penalty (TLP), which can maintain correct Type I error rates while yielding high statistical power across a wide range of alternatives. To calculate its

Indexed as

Adaptive TestGene-Environmental InteractionTruncated Lasso Penalty

Identifiers

PMID32802002
PMCPMC7425805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.