Evidence map›Paper›PMID 32801998›Full record

ArticleMediators of inflammation2020

Imbalance in PB IL-17-Secreting and Regulatory Cells in Pars Planitis Is Associated with Dysregulation of IFN-

Agata Kosmaczewska, Joanna Przeździecka-Dołyk, Anna Turno-Kręcicka, Lidia Ciszak, Aleksandra Szteblich, Agnieszka Węgrzyn, Irena Frydecka, Marta Misiuk-Hojło

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Agata KosmaczewskaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-3805-9476
Joanna Przeździecka-DołykDepartment and Clinic of Ophthalmology, Faculty of Postgraduate Medicine, Medical University of Wroclaw, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-1099-4876
Anna Turno-KręcickaDepartment and Clinic of Ophthalmology, Faculty of Postgraduate Medicine, Medical University of Wroclaw, Wroclaw, Poland.
Lidia CiszakHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.ORCID https://orcid.org/0000-0002-5135-6336
Aleksandra SzteblichHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Agnieszka WęgrzynŁukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland.ORCID https://orcid.org/0000-0001-9502-9911
Irena FrydeckaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Marta Misiuk-HojłoDepartment and Clinic of Ophthalmology, Faculty of Postgraduate Medicine, Medical University of Wroclaw, Wroclaw, Poland.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLUniversity of Wrocław · PLŁukasiewicz Research Network – PORT Polish Center for Technology Development · PLWrocław University of Science and Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

resultsIn patients, an increase in the population of Th17-secreting cells negatively correlated with the abundance of both IFN-

conclusionsIn pars planitis, the alterations in lymphocyte cell distribution affect primarily the T cell repertoire. The imbalance in PB Th1/Th17/Treg cells creates proinflammatory conditions, strengthening the suggestion that the immune background may play a role in pars planitis pathogenesis. Also, circulating Th1 level may be of potential clinical relevance in terms of prediction of a more severe course of the disease.

Indexed as

AdolescentAdultAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleFlow CytometryHumansInterferon-gammaInterleukin-17MaleMiddle AgedPars PlanitisTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryInterferon-gammaInterleukin-17

Identifiers

PMID32801998
PMCPMC7415078
OpenAlexW3046432800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.