Evidence map›Paper›PMID 32801992›Full record

ArticleMediators of inflammation2020

Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition.

Ying Liu, Xinyue Cui, Ming-Qing Gao, Meilan Xue, Hongwei Xu, Zhishang Chang, Yushan Jiang, Hui Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ying Liu *Basic Medical College, Qingdao University, Qingdao, 266071 Shandong, China.
Xinyue Cui *Department of Human Nutrition, College of Public Health, Qingdao University, Qingdao, 266071 Shandong, China.
Ming-Qing GaoSchool of Medicine, Northwest University, Xi'an, 710069 Shaanxi, China.ORCID https://orcid.org/0000-0002-8904-7758
Meilan XueBasic Medical College, Qingdao University, Qingdao, 266071 Shandong, China.ORCID https://orcid.org/0000-0002-7296-0778
Hongwei XuBasic Medical College, Qingdao University, Qingdao, 266071 Shandong, China.
Zhishang ChangLaboratory of Biomedical Center, Qingdao University, Qingdao, 266021 Shandong, China.
Yushan JiangDepartment of Human Nutrition, College of Public Health, Qingdao University, Qingdao, 266071 Shandong, China.
Hui LiangDepartment of Human Nutrition, College of Public Health, Qingdao University, Qingdao, 266071 Shandong, China.ORCID https://orcid.org/0000-0003-4702-8468
Qingdao University · CNNorthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aplysin is a brominated sesquiterpene with an isoprene skeleton and has biological activities. The purpose of this study is to investigate the inhibitory effect of aplysin on spontaneous pancreatic necrosis in nonobese diabetic (NOD) mice and its potential mechanisms. Results showed that NOD mice at 12 weeks of age showed obvious spontaneous pancreatic necrosis, damaged tight junctions of intestinal epithelia, and widened gaps in tight and adherens junctions. Aplysin intervention was able to alleviate spontaneous pancreatic necrosis in NOD mice, accompanied with decreased serum endotoxin levels and downregulated expressions of Toll-like receptor 4 and its related molecules MyD88, TRAF-6, NF-

Indexed as

AnimalsBlotting, WesternEnzyme-Linked Immunosorbent AssayFemaleGastrointestinal MicrobiomeHydrocarbons, BrominatedInflammationMiceMice, Inbred NODMicroscopy, Electron, TransmissionNecrosisRNA, Ribosomal, 16SSesquiterpenesSignal TransductionaplysinHydrocarbons, BrominatedRNA, Ribosomal, 16SSesquiterpenes

Identifiers

PMID32801992
PMCPMC7416259
OpenAlexW3046663821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.