Evidence map›Paper›PMID 32801981›Full record

ArticleJournal of blood medicine2020

Clinical Phenotype and Response to Different Lines of Therapy in Elderly with Immune Thrombocytopenia: A Retrospective Study.

Salvatrice Mancuso, Melania Carlisi, Nicola Serra, Mariasanta Napolitano, Simona Raso, Ugo Consoli, Roberto Palazzolo, Maria Rosa Lanza Cariccio, Sergio Siragusa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of blood medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Salvatrice MancusoHealth Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, Palermo, Italy.
Melania CarlisiHealth Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, Palermo, Italy.
Nicola SerraDepartment of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, Italy.
Mariasanta NapolitanoHealth Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, Palermo, Italy.ORCID 0000-0001-8934-2936
Simona RasoDepartment of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Palermo, Italy.ORCID 0000-0002-0967-2191
Ugo ConsoliUOC Ematologia ARNAS Garibaldi, Catania, Italy.
Roberto PalazzoloUOS Ematologia, Asst Valtellina e Alto Lario, Sondrio, Italy.
Maria Rosa Lanza CariccioDipartimento Oncologico, La Maddalena, UOC Di Oncoematologia e TMO, Palermo, Italy.
Sergio SiragusaHealth Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, Palermo, Italy.
University of Palermo · ITAzienda Socio Sanitaria Territoriale della Valtellina e Alto Lario · ITLa Maddalena · ITOspedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInsufficient knowledge of primary immune thrombocytopenia purpura (ITP) in the elderly, together with a lack of clinical trial data, has resulted in wide variation in treatments. Here, we present a study focused on clinical characteristics of ITP in older subjects at diagnosis integrated with the subsequent course of the disease and treatment history.

methodsIn a retrospective monoinstitutional study, we evaluated >65-year-old patients with primary ITP. Clinical characteristics at the time of diagnosis were described and analyzed. We aimed to delineate whether subsequent lines of therapy influenced the number of relapses. In addition to initial regimens, we reported subsequent treatments and the impact on relapse trends.

resultsA total of 50 patients (56% males, mean age 78 years) were included. With regard to clinical variables at diagnosis, statistical significance was found for Eastern Cooperative Oncology Group performance status 1 (46% of patients,

conclusionITP in older age poses considerable challenges, so specific management strategies should be considered to optimize outcomes. Our findings provide evidence of an inverse relationship between lines of therapy and timing of relapses. This study does not exclude the possibility that agents used after first-line therapy may have an impact on the response and modify the unfavorable course of ITP.

Indexed as

agingimmunogeriatricsITPITP treatmentprimary immune thrombocytopeniaTpo-receptor agonist

Identifiers

PMID32801981
PMCPMC7415458
OpenAlexW3047453450

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.