Evidence map›Paper›PMID 32801883›Full record

ArticleCancer management and research2020

Risk Stratification Based on Metastatic Pelvic Lymph Node Status in Stage IIIC1p Cervical Cancer.

Anyang Li, Luhui Wang, Qi Jiang, Wenlie Wu, Baoyou Huang, Haiyan Zhu

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PubMed Full text at PMC Publisher
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Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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7citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The distribution pattern of pelvic lymph nodal metastases in cervical cancer.Journal of cancer research and clinical oncology · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anyang LiDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200126, People's Republic of China.
Luhui WangDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Qi JiangDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Wenlie WuDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Baoyou HuangDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.
Haiyan ZhuDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200126, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStage IIIC1 cervical cancer showed heterogeneous in oncologic outcomes with highly variable survival rates. Our objective was to determine the prognostic significance of removed and metastatic pelvic lymph node status and further perform risk stratification in patients with stage IIIC1p cervical cancer. PATIENTS AND

methodsPatients with stage IIIC1p cervical cancer and undergoing radical hysterectomy with lymphadenectomy in 2008-2018 were retrospectively analyzed. Patients' stage was classified using the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging schema. Univariate and multivariable models were used to examine the association between removed and metastatic lymph node status and recurrence-free survival/overall survival.

resultsDuring a median follow-up of 34 months, 73 relapses and 44 deaths were observed among 273 patients with stage IIIC1p cervical cancer. Parametrial involvement and metastatic lymph node ratio (mLNR) were identified as independent predictors for recurrence-free survival. Parametrial involvement and mLNR were independent predictors for overall survival. A stratification system was then created based on parametrial involvement and mLNR. A total of 123 (45.1%), 127 (46.5%) and 23 (8.4%) patients were classified into the low-risk, intermediate-risk, and high-risk groups, with as a 5-year recurrence-free survival of 81.7%, 51.1%, 38%, respectively. Compared to the low-risk group, the intermediate- and high-risk groups had a significantly greater risk of recurrence and death.

conclusionThe prognosis of stage IIIC1p patients varied significantly. A risk stratification system based on parametrial involvement and mLNR successfully separated patients into low, intermediate, and high-risk group. Our findings could facilitate the practical use of further stratification in Stage IIIC1p cervical cancer.

Indexed as

cervical cancerpelvic lymph nodeprognosisstage IIIC1p

Identifiers

PMID32801883
PMCPMC7395696

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