ArticleInfection and drug resistance2020
Difference in Biomarkers Between COVID-19 Patients and Other Pulmonary Infection Patients.
Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?International journal of laboratory hematology · 2022Article
- Prospective selected biomarkers in COVID-19 diagnosis and treatment.Biomarkers in medicine · 2021Article
- Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform.Sensors (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pandemic due to the novel coronavirus disease 2019 (COVID-19) has resulted in an increasing number of patients need to be tested. We aimed to determine if the use of integrated laboratory data can discriminate COVID-19 patients from other pulmonary infection patients.
methodsThis retrospective cohort study was conducted at Kunming Third People's Hospital in China from January 20 to February 28, 2020. Medical records and laboratory data were extracted and combined for COVID-19 and other pulmonary infection patients on admission. A partial least square discriminant analysis (PLS-DA) model was constructed and calibrated to discriminate COVID-19 from other pulmonary infection patients.
resultsCOVID-19 patients diagnosed and treated in Kunming were balanced in terms of sex and covered all age groups. Most of them were mild cases; only five were severe cases. The first two dimensions of the PLS-DA model could classify COVID-19 and other pulmonary infection patients with an accuracy of 96.6% (95.1% in the cross-validation model). Basophil count, the proportion of basophils, prothrombin time, prothrombin time activity, and international normalized ratio were the five most discriminant biomarkers.
conclusionIntegration of biomarkers can discriminate COVID-19 patients from other pulmonary infections on admission to hospital and thus may be a supplement to nucleic acid tests.
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