Evidence map›Paper›PMID 32801761›Full record

ArticleOncoTargets and therapy2020

3,6-Disubstituted 1,2,4-Triazolo[3,4-

Sofia Sagredou, Panagiotis Dalezis, Nikolaos Nikoleousakos, Michail Nikolaou, Maria Voura, Konstantinos Almpanakis, Mihalis I Panayiotidis, Vasiliki Sarli, Dimitrios T Trafalis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Double-headed nucleosides: Synthesis and applications.Beilstein journal of organic chemistry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sofia SagredouLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
Panagiotis DalezisLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.ORCID 0000-0001-7680-7685
Nikolaos NikoleousakosLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
Michail NikolaouLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.ORCID 0000-0002-7215-6296
Maria VouraDepartment of Chemistry, Aristotle University of Thessaloniki , Thessaloniki, 54124, Greece.ORCID 0000-0003-0455-0598
Konstantinos AlmpanakisDepartment of Chemistry, Aristotle University of Thessaloniki , Thessaloniki, 54124, Greece.
Mihalis I PanayiotidisDepartment of Electron Microscopy & Molecular Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.ORCID 0000-0002-1450-3552
Vasiliki SarliDepartment of Chemistry, Aristotle University of Thessaloniki , Thessaloniki, 54124, Greece.ORCID 0000-0002-6128-8277
Dimitrios T TrafalisLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece.
National and Kapodistrian University of Athens · GRAristotle University of Thessaloniki · GRCyprus Institute of Neurology and Genetics · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTopoisomerase IIα (topIIα) maintains the topology of DNA in order to ensure the proper functioning of numerous DNA processes. Inhibition of topIIα leads to the killing of cancer cells thus constituting such inhibitors as useful tools in cancer therapeutics. Triazolo[3,4- MATERIALS AND

methodsThe MTT assay was performed in DLD-1, HT-29, and LoVo cancer cells so as to evaluate the antiproliferative activity of KA25, KA26, and KA39 triazolo[3,4-

resultsAll three triazolo[3,4-

conclusionAmong the three triazolo[3,4-

Indexed as

catalytic cyclephosphorylationSer-1106thiadiazolestopoisomerase IIαtriazoles

Identifiers

PMID32801761
PMCPMC7395825
OpenAlexW3044850652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.