ReviewJournal of multidisciplinary healthcare2020
Reflections on Atherosclerosis: Lesson from the Past and Future Research Directions.
Review in Journal of multidisciplinary healthcare, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Aortic Atherosclerosis: An Updated Review of Current Guidelines and Management Approach-A Literature Review.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026Article
- Ceramide as a key regulatory factor in the impact of dietary inflammatory index on plaque stability.Scientific reports · 2026Article
- Review
- Lipoprotein(a): Assessing the Current Knowledge and Gaps in Screening and Treatment-A Narrative Review.Journal of cardiovascular development and disease · 2025Review
- Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies.Biosensors · 2025Review
- Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoEBMC cardiovascular disorders · 2025Article
- Cellular aspects of immunity involved in the development of atherosclerosis.Frontiers in immunology · 2025Review
- Involvement of Lipids and Lipid Mediators in Inflammation and Atherogenesis.Current medicinal chemistry · 2025Review
- Molecular Links and Clinical Effects of Inflammation and Metabolic Background on Ischemic Stroke: An Update Review.Journal of clinical medicine · 2024Review
- Novel Mouse Model of Late-Stage Coronary Atherosclerosis With Features of Plaque Rupture and Stroke.Circulation · 2024Article
- Akira Endo: Father of Statins.Cureus · 2024Review
- A novel rabbit model of atherosclerotic vulnerable plaque established by cryofluid-induced endothelial injury.Scientific reports · 2024Article
- Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.JCI insight · 2024Article
- Re-analysis of single-cell transcriptomics reveals a critical role of macrophage-like smooth muscle cells in advanced atherosclerotic plaque.Theranostics · 2024Article
- Prediction and validation of common targets in atherosclerosis and non-small cell lung cancer influenced by atorvastatin.BMC complementary medicine and therapies · 2023Article
- Lipids in Atherosclerosis: Pathophysiology and the Role of Calculated Lipid Indices in Assessing Cardiovascular Risk in Patients with Hyperlipidemia.International journal of molecular sciences · 2022Review
- Features of the metabolic syndrome and subclinical atherosclerosis in patients with cerebrotendinous xanthomatosis: An augmented risk for premature cardiovascular disease.Frontiers in genetics · 2022Article
- Anti-Inflammatory Effects of Thymoquinone in Atherosclerosis: A Mini Review.Frontiers in pharmacology · 2021Review
- Identifying RBM47, HCK, CD53, TYROBP, and HAVCR2 as Hub Genes in Advanced Atherosclerotic Plaques by Network-Based Analysis and Validation.Frontiers in genetics · 2020Article
- Pan-vascular disease: what we have done in the past and what we can do in the future?Cardiology plusArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical manifestations of atherosclerosis are nowadays the main cause of death in industrialized countries, but atherosclerotic disease was found in humans who lived thousands of years ago, before the spread of current risk factors. Atherosclerotic lesions were identified on a 5300-year-old mummy, as well as in Egyptian mummies and other ancient civilizations. For many decades of the twentieth century, atherosclerosis was considered a degenerative disease, mainly determined by a passive lipid storage, while the most recent theory of atherogenesis is based on endothelial dysfunction. The importance of inflammation and immunity in atherosclerosis's pathophysiology was realized around the turn of the millennium, when in 1999 the famous pathologist Russell Ross published in the New England Journal of Medicine an article entitled "Atherosclerosis - an inflammatory disease". In the following decades, inflammation has been a topic of intense basic research in atherosclerosis, albeit its importance has ancient scientific roots. In fact, in 1856 Rudolph Virchow was the first proponent of this hypothesis, but evidence of the key role of inflammation in atherogenesis occurred only in 2017. It seemed interesting to retrace the key steps of atherosclerosis in a historical context: from the teachings of the physicians of the Roman Empire to the response-to-injury hypothesis, up to the key role of inflammation and immunity at various stages of disease. Finally, we briefly discussed current knowledge and future trajectories of atherosclerosis research and its therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.