Evidence map›Paper›PMID 32801693›Full record

ArticleInternational journal of nanomedicine2020

Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral

Omnia Hesham Abdelhafez, Taha Farouk Shehata Ali, John Refaat Fahim, Samar Yehia Desoukey, Safwat Ahmed, Fathy A Behery, Mohamed Salah Kamel, Tobias A M Gulder, Usama Ramadan Abdelmohsen

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  3. Biofabrication of Silver Nanoparticles UsingLife (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omnia Hesham AbdelhafezDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.
Taha Farouk Shehata AliDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-8881-0408
John Refaat FahimDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Samar Yehia DesoukeyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Safwat AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Fathy A BeheryDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Mohamed Salah KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Tobias A M GulderChair of Technical Biochemistry, Department of Chemistry and Food Chemistry, Technical University of Dresden, Dresden 01069, Germany.
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSoft corals have been endorsed as a plentiful source of bioactive compounds with promising anti-inflammatory activities; therefore, exploring their potential as source of anti-inflammatory metabolites has stimulated a growing research interest. PURPOSE: To investigate the anti-inflammatory potential of the soft coral, MATERIALS AND

methodsThe petroleum ether and ethyl acetate fractions were used to synthesize silver nanoparticles. The prepared silver nanoparticles were characterized through UV-vis spectrophotometric, transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR) analyses. Testing for the anti-inflammatory activity was performed against COX-1 and COX-2. Furthermore, liquid chromatography-mass spectrometry (LC-MS) based metabolomics analysis and molecular docking were also applied.

resultsA variety of secondary metabolites were identified, among them, sesquiterpenes were found to prevail. The petroleum ether and acetone fractions of

conclusionThe obtained results showed the effectiveness of non-targeted metabolomics technique in metabolic profiling of

Indexed as

AlkanesAnimalsAnthozoaAnti-Inflammatory AgentsCyclooxygenase 1Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsGreen Chemistry TechnologyHumansMetabolomicsMetal NanoparticlesMolecular Docking SimulationSecondary MetabolismSesquiterpenesSilverSpectrometry, Mass, Electrospray IonizationAlkanesAnti-Inflammatory AgentsCyclooxygenase 1Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsnaphthaPTGS1 protein, humanSesquiterpenesSilveranti-inflammatorymetabolomicsmolecular dockingnanoparticlesNephtheasoft coral

Identifiers

PMID32801693
PMCPMC7395700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.