Observational studyNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Long-term antibiotic use during early life and risks to mental traits: an observational study and gene-environment-wide interaction study in UK Biobank cohort.
Observational study in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Gene-Environment Interaction Loci Associated with Refractive Error: SCAMPI Analysis.Ophthalmology science · 2026Article
- Elevated Copper Level in Schizophrenia Results in Neurotransmitter and Cognitive Alteration.Biological trace element research · 2026Article
- Extensive antibiotic use during early life and risk of frailty: a population-based cohort study in the UK biobank.BMC public health · 2026Article
- The dual-sensitive period gut-brain crosstalk, neuroinflammation, and the biological roots of adolescent depression.Frontiers in immunology · 2026Review
- Effect of antibiotics on physical and physiological development of children under 5-A scoping review.Journal of education and health promotion · 2024Article
- Age at first exposure to antibiotics and neurodevelopmental outcomes in childhood.Psychopharmacology · 2023Article
- Article
- Role of the gut microbiome in three major psychiatric disorders.Psychological medicine · 2022Review
- ProbioticNutrients · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationships between long-term antibiotic use during early life and mental traits remain elusive now. A total of 158,444 subjects from UK Biobank were used in this study. Linear regression analyses were first conducted to assess the correlations between long-term antibiotic use during early life and mental traits. Gene-environment-wide interaction study (GEWIS) was then performed by PLINK2.0 to detect the interaction effects between long-term antibiotic use during early life and genes on the risks of mental traits. Finally, DAVID tool was used to conduct gene ontology (GO) analysis of the identified genes interacting with long-term antibiotic use during early life. We found negative associations of long-term antibiotic use during early life with remembrance (p value=1.74 × 10
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Registered trials
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