ArticleJournal of epidemiology2021
Night Work, Rotating Shift Work, and the Risk of Cancer in Japanese Men and Women: The JACC Study.
Article in Journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Is Night Shift Work Associated with Ovarian Cancer? A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Association between night work and prostate cancer: a systematic review and meta-analysis.International archives of occupational and environmental health · 2024Pooled it
- Night-shift work duration and breast cancer risk: an updated systematic review and meta-analysis.BMC women's health · 2021Pooled it
- Night shift work and risk of total and site-specific cancer: results from a prospective cohort study among Chinese men.Scandinavian journal of work, environment & health · 2026Article
- Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer.Non-coding RNA research · 2026Article
- Hepatocellular Carcinoma Around the Clock.Current oncology (Toronto, Ont.) · 2026Review
- Circadian rhythm in gastrointestinal cancer: clinical applications and future perspectives.Annals of medicine · 2025Review
- The multifaceted impact of circadian disruption on cancer risk: a systematic review of insights and economic implications.Journal of the National Cancer Center · 2025Review
- Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice.Investigative ophthalmology & visual science · 2025Article
- Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice.Journal of clinical biochemistry and nutrition · 2025Article
- Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift.Scientific reports · 2025Article
- Effect of circadian rhythm disruption induced by time-restricted feeding and exercise on oxidative stress and immune in mice.Journal of clinical biochemistry and nutrition · 2025Article
- Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.Hepatoma research · 2024Article
- Impact of sleep on gastrointestinal cancer.World journal of clinical oncology · 2024Article
- A review for the impacts of circadian disturbance on urological cancers.Sleep and biological rhythms · 2024Review
- A Narrative Review of the Carcinogenic Effect of Night Shift and the Potential Protective Role of Melatonin.Cureus · 2023Review
- Are sleep duration, sleep apnea, and shift work associated with colorectal cancer risk?Journal of gastrointestinal oncology · 2023Article
- Metabolomic profiles in night shift workers: A cross-sectional study on hospital female nurses.Frontiers in public health · 2023Article
- Uncovering Novel Biomarkers of Inflammation as Potential Screening Targets of Disease Risk in Healthcare Shift Workers: A Pilot Study.International journal of nursing and health care research · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited epidemiological evidence has suggested a positive relationship between night shift work and the risk of cancer. Herein, we investigated the prospective association between different forms of work schedule and the risk of numerous cancers and all-cause cancer among Japanese men and women.
methodsThis cohort study included 45,390 working men and women aged 40-79 years and registered in the Japan Collaborative Cohort Study (JACC Study). The Cox proportional hazards models were used to calculate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for incident cancer among those who reported engagement in night work and rotating shift work for their longest occupations compared with day work.
resultsWithin a median follow-up duration of 14.2 years, 2,283 (9.4%) men and 1,309 (4.5%) women developed cancer. Among men, rotating shift work was significantly associated with increased risk of esophageal cancer (HR 2.47; 95% CI, 1.42-4.31) and decreased risk of liver cancer (HR 0.54; 95% CI, 0.30-0.98). Also, rotating shift work tended to be associated with the increased risk of prostate cancer (HR 1.42; 95% CI, 0.95-2.12). Night work and rotating shift work were not related to the risk of all-cause cancer in either sex.
conclusionRotating shift work might contribute to the increased risk of esophageal cancer and prostate cancer and the decreased risk of liver cancer among Japanese men.
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