Evidence map›Paper›PMID 32801213›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca

Horia Vais, Riley Payne, Usha Paudel, Carmen Li, J Kevin Foskett

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Mechanistic Modeling of MCUx Gatekeeping, CaAmerican journal of physiology. Cell physiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  6. Article
  7. MAM-STAT3-Driven Mitochondrial CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Article
  9. Article
  10. MRS2 missense variation at Asp216 abrogates inhibitory MgProtein science : a publication of the Protein Society · 2024
    Article
  11. Article
  12. Article
  13. Tissue-specific differences in CaPhysiological reports · 2024
    Article
  14. Review
  15. Review
  16. Cytosolic CaBiophysical reports · 2023
    Article
  17. MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Horia VaisDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-6377-0622
Riley PayneDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Usha PaudelDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Carmen LiDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-6267-4284
J Kevin FoskettDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; foskett@pennmedicine.upenn.edu.ORCID 0000-0002-8854-0268
University of Pennsylvania · US

Funding

Electrophysiology of nuclear membrane InsP3 receptorR37GM056328 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2011 to 2020
$4.9M
Molecular physiology of intracellular InsP3R and MCU ion channelsR35GM140975 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2021 to 2025
$2.2M
NIGMS NIH HHS R35 GM140975NIGMS NIH HHS R37 GM056328
6 · The paper itself

Abstract

Ca

Indexed as

ApoptosisBiological TransportCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsCytoplasmCytosolHEK293 CellsHeLa CellsHumansMembrane Potential, MitochondrialMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsOxidation-ReductionCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsMICU1 protein, humanmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinsSMDT1 protein, humancalciumelectrophysiologyEMREMICU1mitochondria

Identifiers

PMID32801213
PMCPMC7474680
OpenAlexW3049005351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.