ArticleProceedings of the National Academy of Sciences of the United States of America2020
Universal free-energy landscape produces efficient and reversible electron bifurcation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bcFEBS open bio · 2026Review
- Molecular strategies for flux control in an electron bifurcation protein.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Article
- From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026Review
- Revisiting H‑BondACS omega · 2025Article
- Design of Light Driven Hole Bifurcating Proteins.ACS central science · 2025Article
- Flexibility and Hydration of the QJournal of chemical information and modeling · 2025Article
- Undulating Free Energy Landscapes Buffer Redox Chains from Environmental Fluctuations.The journal of physical chemistry. B · 2024Article
- Structures and Electron Transport Paths in the Four Families of Flavin-Based Electron Bifurcation Enzymes.Sub-cellular biochemistry · 2024Review
- Syntrophic Propionate Oxidation: One of the Rate-Limiting Steps of Organic Matter Decomposition in Anoxic Environments.Applied and environmental microbiology · 2023Review
- Correlated particle transport enables biological free energy transduction.Biophysical journal · 2023Article
- Exploring Proton-Coupled Electron Transfer at Multiple Scales.Nature computational science · 2023Article
- Q-lipid-containing membranes show high in-plane conductivity using a membrane-on-a-chip setup.iScience · 2023Article
- Machine Learning for Efficient Prediction of Protein Redox Potential: The Flavoproteins Case.Journal of chemical information and modeling · 2022Article
- Site-Differentiated Iron-Sulfur Cluster Ligation Affects Flavin-Based Electron Bifurcation Activity.Metabolites · 2022Article
- Kinetic model for reversible radical transfer in ribonucleotide reductase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An uncharacteristically low-potential flavin governs the energy landscape of electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Free Energies of Proton-Coupled Electron Transfer Reagents and Their Applications.Chemical reviews · 2022Review
- Multiple hops move electrons from bacteria to rocks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Why Do Most Aromatics Fail to Support Hole Hopping in the CytochromeThe journal of physical chemistry. B · 2021Article
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5 authors.
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Abstract
For decades, it was unknown how electron-bifurcating systems in nature prevented energy-wasting short-circuiting reactions that have large driving forces, so synthetic electron-bifurcating molecular machines could not be designed and built. The underpinning free-energy landscapes for electron bifurcation were also enigmatic. We predict that a simple and universal free-energy landscape enables electron bifurcation, and we show that it enables high-efficiency bifurcation with limited short-circuiting (the EB scheme). The landscape relies on steep free-energy slopes in the two redox branches to insulate against short-circuiting using an electron occupancy blockade effect, without relying on nuanced changes in the microscopic rate constants for the short-circuiting reactions. The EB scheme thus unifies a body of observations on biological catalysis and energy conversion, and the scheme provides a blueprint to guide future campaigns to establish synthetic electron bifurcation machines.
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