ArticleBMJ open2020
Low-density lipoprotein cholesterol and all-cause mortality: findings from the China health and retirement longitudinal study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Low apolipoprotein B and LDL-cholesterol are associated with the risk of cardiovascular and all-cause mortality: a prospective cohort.Annals of medicine · 2025Article
- Absolute impact of lipid levels on coronary heart disease in a real-world primary prevention cohort of 730,236 people.American journal of preventive cardiology · 2025Article
- Remnant cholesterol shows inverse and nonlinear associations with leukocyte telomere length and serum α-Klotho, mediated by inflammation and oxidative stress.Frontiers in endocrinology · 2025Article
- Call for a consensual definition of dyslipidemia in coronary angiography trials.Frontiers in cardiovascular medicine · 2025Review
- Association between low-density lipoprotein cholesterol levels and all-cause mortality in patients with coronary artery disease: a real-world analysis using data from an international network.Scientific reports · 2024Article
- Association between serum lipid and all-cause mortality in asthmatic populations: a cohort study.Lipids in health and disease · 2024Article
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- Serum Lipid Profiles and All-Cause Mortality: A Retrospective Single Center Study on Chinese Inpatient Centenarians.Frontiers in public health · 2022Article
- Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999-2014.Scientific reports · 2021Article
- Low density lipoprotein cholesterol and all-cause mortality rate: findings from a study on Japanese community-dwelling persons.Lipids in health and disease · 2021Article
- Outcomes of Ischemic Stroke and Associated Factors Among Elderly Patients With Large-Artery Atherosclerosis: A Hospital-Based Follow-Up Study in China.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the relationship between low-density lipoprotein cholesterol (LDL-C) and all-cause mortality among middle-aged and elderly Chinese population.
designProspective cohort study.
settingThis study used data from the China Health and Retirement Longitudinal Study.
participantsMiddle-aged and elderly participants with complete data were enrolled for a 4-year follow-up of total mortality and plasma levels of LDL-C, including 4981 male respondents and 5529 female respondents.
resultsDuring a 4-year follow-up, there were 305 and 219 deaths in men and women, respectively. Compared with the first quintile (Q1) of LDL-C, the adjusted HRs (95% CIs) were 0.818 (0.531 to 1.260) for Q2, 0.782 (0.507 to 1.208) for Q3, 0.605 (0.381 to 0.962) for Q4 and 0.803 (0.506 to 1.274) for Q5 in men. The results from restricted cubic spine (RCS) showed that when the 20th percentile of LDL-C levels (84 mg/dL) was used as the reference, a lower LDL-C concentration (<84 mg/dL) was associated with a higher 4-year all-cause mortality risk. By contrast, both quintile analysis and RCS analysis did not show a statistically significant association in women.
conclusionsCompared with moderately elevated LDL-C (eg, 117-137 mg/dL), a lower plasma level of LDL-C (eg, ≤84 mg/dL) was associated with an increased risk of 4-year all-cause mortality in middle-aged and elderly Chinese men. The results suggest the potential harmful effect of a quite low level of LDL-C on total mortality.
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