Evidence map›Paper›PMID 32801153›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Cell-Type-Specific Gene Inactivation and

Xue Liu, Liang Ma, Hongzhi Liu, Jingwen Gan, Yidan Xu, Tianrui Zhang, Peiyuan Mu, Jinyun Wu, Yun Shi, Yubin Zhang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xue LiuDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Liang MaDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hongzhi LiuDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jingwen GanDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yidan XuDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Tianrui ZhangDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID 0000-0002-5712-3437
Peiyuan MuDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jinyun WuDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yun ShiDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yubin ZhangDepartment of Toxicology, School of Public Health, Fudan University, Shanghai, 200032, China.ORCID 0000-0002-7114-3485
Ling GongDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Miao HeDepartment of Neurology, State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China hem@fudan.edu.cn.ORCID 0000-0003-0731-6801
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conditional gene inactivation and restoration are powerful tools for studying gene functions in the nervous system and for modeling neuropsychiatric diseases. The combination of the two is necessary to interrogate specific cell types within defined developmental stages. However, very few methods and animal models have been developed for such purpose. Here we present a versatile method for conditional gene inactivation and

Indexed as

PhenotypeAnimalsDNA NucleotidyltransferasesGene TargetingGerm-Line MutationIntegrasesMaleMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMovementNeuronsRett SyndromeCre recombinaseDNA NucleotidyltransferasesFLP recombinaseIntegrasesMecp2 protein, mouseMethyl-CpG-Binding Protein 2cell typeconditional gene inactivation and restorationCre and FlpMecp2mouse modelRett syndrome

Identifiers

PMID32801153
PMCPMC7480235
OpenAlexW3048927360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.