Evidence map›Paper›PMID 32801151›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.

Candler Paige, Priscilla A Barba-Escobedo, Jennifer Mecklenburg, Mayur Patil, Vincent Goffin, David R Grattan, Gregory Dussor, Armen N Akopian, Theodore J Price

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Review
  8. Review
  9. Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025
    Review
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  18. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Candler PaigeSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, Texas 75080.
Priscilla A Barba-EscobedoDepartments of Endodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Jennifer MecklenburgDepartments of Endodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Mayur PatilDepartments of Endodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Vincent GoffinUniversité de Paris, Institut National de la Santé et de la Recherche Médicale U1151, Paris, 75014, France.
David R GrattanCentre for Neuroendocrinology and Department of Anatomy, University of Otago School of Biomedical Sciences, Dunedin 09001, New Zealand.ORCID 0000-0001-5606-2559
Gregory DussorSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, Texas 75080.ORCID 0000-0002-1193-9238
Armen N AkopianDepartments of Endodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 Akopian@UTHSCSA.edu Theodore.Price@utdallas.edu.
Theodore J PriceSchool of Behavioral and Brain Sciences and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, Texas 75080 Akopian@UTHSCSA.edu Theodore.Price@utdallas.edu.ORCID 0000-0002-6971-6221
The University of Texas Health Science Center at San Antonio · USThe University of Texas at Dallas · USInserm · FRUniversity of Otago · NZ

Funding

Translation Control of Pain PlasticityR01NS065926 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PRICE, THEODORE J. · 2010 to 2023
$5.7M
Sex-specific regulation of local translation and chronic pain mechanisms in femalesR01NS102161 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI AKOPIAN, ARMEN N, PRICE, THEODORE J. · 2018 to 2022
$2.5M
Prolactin regulation of postoperative pain in males and femalesR01GM112747 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N · 2015 to 2018
$1.2M
Identification of Sex Specific Regulatory Drug Targets for Chronic Neuropathic PainF99NS113457 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI PAIGE, CANDLER ANN · 2019 to 2020
$81k
NIGMS NIH HHS R01 GM112747NINDS NIH HHS F99 NS113457NINDS NIH HHS R01 NS065926NINDS NIH HHS R01 NS102161
6 · The paper itself

Abstract

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE

Indexed as

NeurosecretionSex CharacteristicsAnimalsDinoprostoneEstrogensFemaleHumansHyperalgesiaInterleukin-6MaleMiceNAV1.8 Voltage-Gated Sodium ChannelNociceptionReceptors, ProlactinSensory Receptor CellsSpinal CordDinoprostoneEstrogensInterleukin-6NAV1.8 Voltage-Gated Sodium ChannelReceptors, ProlactinScn10a protein, mouseestrogennociceptorprolactinsex dimorphismtestosteronetranslation regulation

Identifiers

PMID32801151
PMCPMC7480243
OpenAlexW3048660319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.