Observational studyScience translational medicine2020
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
109 citing papers in PubMed, 164 citations in OpenAlex.
- Effect of mixed probiotics on pulmonary flora in patients with mechanical ventilation: an exploratory randomized intervention study.European journal of medical research · 2024Trial
- The role of the respiratory microbiome in acute and chronic respiratory diseases.Nature reviews. Microbiology · 2026Review
- Gut microbiota-immune-metabolic crosstalk in acute lung injury: integrating the gut-lung axis from mechanism to therapeutic targeting.Seminars in immunopathology · 2026Review
- Development of a gene-editing strategy to overcome genetic intractability inJournal of bacteriology · 2026Article
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- The gut-lung axis in early life: microbiome-associated mechanisms and clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- The Role of the Pentose Phosphate Pathway in Cardiovascular Diseases.Cardiovascular drugs and therapy · 2026Review
- The Role of the Respiratory Microbiome in Pneumonia.Clinics in chest medicine · 2026Review
- Bacterial taxa associated with lung cancer cases in Southeast Asians: a pilot case-control study.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Gut microbiota-mediated short-chain fatty acids contribute to the protective effects of Xiaoxuming decoction against lipopolysaccharide-induced acute lung injury.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.Medical gas research · 2026Review
- Gut-lung axis perturbation andiScience · 2026Article
- Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury.BMJ open respiratory research · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- The neonatal lung microbiome: a dynamic determinant of respiratory health, disease, and novel therapeutics.Frontiers in pediatrics · 2026Review
- The gut-lung axis: pathological crosstalk and inter-organ communication in chronic obstructive pulmonary disease and inflammatory bowel disease.Frontiers in immunology · 2026Review
- Gut microbiome-mediated nutrients alter opportunistic bacterial growth in peritonitis.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Towards airway microbiome engineering for improving respiratory health.Advanced drug delivery reviews · 2025Review
- Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota.Journal of bacteriology · 2025Review
- Longitudinal analysis of lung microbiome, immune response, and metabolism in ventilator-associated pneumonia: a cohort study.Critical care (London, England) · 2025Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Shanna L AshleyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-7685-0031
Michael W SjodingDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Antonia P PopovaDivision of Pediatric Pulmonology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-0404-6124
Tracy X CuiDivision of Pediatric Pulmonology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-2325-8907
Matthew J HoostalDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-3429-7706
Thomas M SchmidtDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
William R BrantonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-6812-0688
Michael G DieterleDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-3109-6151
Nicole R FalkowskiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Jennifer M BakerDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-1363-1525
Kevin J HinkleDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-3719-5038
Kristine E KonopkaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
John R Erb-DownwardDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-4233-758X
Gary B HuffnagleDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Robert P DicksonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. rodickso@med.umich.edu.ORCID 0000-0002-6875-4277
University of Michigan · US
Funding
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MLung Immunopathology Training Stipend SupplementT32HL007517 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKACS, NICHOLAS W · 1985 to 2022
$6.1MFunctional Analysis of the Pulmonary Microbiome during COPDR01HL121774 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUFFNAGLE, GARY B · 2017 to 2020
$3.1MThe role of the lung microbiome in oxygen-induced lung injuryR01HL144599 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2019 to 2023
$2.1MEarly life hyperoxic exposure, lung innate immune responses, bronchopulmonary dysplasia and asthmaR01HL140572 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POPOVA, ANTONIA PETROVA · 2018 to 2022
$1.9MImpacts of Molecular Oxygen on the Structure and Function of the Intestinal MicroR01GM099549 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRATE, JAY W, SCHMIDT, THOMAS M · 2013 to 2016
$1.1MData-Driven Identification of the Acute Respiratory Distress SyndromeK01HL136687 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SJODING, MICHAEL WILLIAM · 2017 to 2021
$862kThe Role of the Microbiome in the Acute Respiratory Distress SyndromeK23HL130641 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2016 to 2020
$859kMesenchymal stromal cells and bronchopulmonary dysplasiaK23HL109149 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POPOVA, ANTONIA PETROVA · 2011 to 2015
$713kRapid pathogen identification in pneumonia using real-time metagenomics and ultrasensitive PCRR21AI137669 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DICKSON, ROBERT PICKETT · 2018 to 2019
$429kNHLBI NIH HHS K01 HL136687NHLBI NIH HHS K23 HL109149NHLBI NIH HHS K23 HL130641NHLBI NIH HHS L30 HL120241NHLBI NIH HHS R01 HL121774NHLBI NIH HHS R01 HL140572NHLBI NIH HHS R01 HL144599NHLBI NIH HHS T32 HL007517NIAID NIH HHS R21 AI137669NIGMS NIH HHS R01 GM099549NIGMS NIH HHS T32 GM007863
Abstract
Inhaled oxygen, although commonly administered to patients with respiratory disease, causes severe lung injury in animals and is associated with poor clinical outcomes in humans. The relationship between hyperoxia, lung and gut microbiota, and lung injury is unknown. Here, we show that hyperoxia conferred a selective relative growth advantage on oxygen-tolerant respiratory microbial species (e.g.,
Indexed as
Gastrointestinal MicrobiomeHyperoxiaLung InjuryAnimalsHumansLungMiceMice, Inbred C57BLOxygenOxygen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.