Evidence map›Paper›PMID 32801116›Full record

ArticleDisease models & mechanisms2020

Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy.

Joshua C Peterson, Lambertus J Wisse, Valerie Wirokromo, Tessa van Herwaarden, Anke M Smits, Adriana C Gittenberger-de Groot, Marie-José T H Goumans, J Conny VanMunsteren, Monique R M Jongbloed, Marco C DeRuiter

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Update in Biomolecular and Genetic Bases of Bicuspid Aortopathy.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Joshua C PetersonDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-5792-2725
Lambertus J WisseDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Valerie WirokromoDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Tessa van HerwaardenDepartment of Chemical Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Anke M SmitsDepartment of Chemical Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Adriana C Gittenberger-de GrootDepartment of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-6062-4112
Marie-José T H GoumansDepartment of Chemical Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-9344-6746
J Conny VanMunsterenDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Monique R M JongbloedDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Marco C DeRuiterDepartment of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands m.c.deruiter@lumc.nl.ORCID 0000-0002-0528-7464
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aortopathy in

Indexed as

Signal TransductionAgingAnimalsAortaAortic DissectionBicuspid Aortic Valve DiseaseDilatation, PathologicDown-RegulationEmbryo, MammalianGene Expression Regulation, DevelopmentalGenetic VariationMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleNeural CrestNitric OxideNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseAortic dissectionBicuspid aortic valveCongenital heart diseaseDevelopmentNitric oxideNOS3

Identifiers

PMID32801116
PMCPMC7541347
OpenAlexW3049152523

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.