Evidence map›Paper›PMID 32801112›Full record

ArticleDrug and alcohol dependence2020

Impact of 12 step mutual help groups on drug use disorder patients across six clinical trials.

Keith Humphreys, Nicolas B Barreto, Sheila M Alessi, Kathleen M Carroll, Paul Crits-Christoph, Dennis M Donovan, John F Kelly, Richard S Schottenfeld, Christine Timko, Todd H Wagner

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  16. Reasons to be cheerful: Personal, civic, and economic achievements after resolving an alcohol or drug problem in the United States population.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keith HumphreysCenter for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, CA, 94025 USA; Department of Psychiatry and Behavioral Sciences, Stanford University, 401 N. Quarry Road, MC: 5717, Stanford, CA 94035 USA. Electronic address: knh@stanford.edu.
Nicolas B BarretoDepartment of Surgery, Stanford University School of Medicine, 291 Campus Drive, Li Ka Shing Building, Stanford, CA, 94305 USA.
Sheila M AlessiDepartment of Psychiatry, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030 USA.
Kathleen M CarrollDepartment of Psychiatry, Yale University, 300 George St., Suite 90, New Haven, CT, 06511 USA.
Paul Crits-ChristophDepartment of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104 USA.
Dennis M DonovanAlcohol and Drug Institute, 1107 NE 45th Street, University of Washington, Box 354805, Seattle, WA 98195 USA.
John F KellyRecovery Research Institute, Center for Addiction Medicine, Harvard Medical School, 151 Merrimac Street 6th Floor, Boston MA 02114 USA.
Richard S SchottenfeldDepartment of Psychiatry, Howard University, 2041 Georgia Avenue, NW, WA, 20060 USA.
Christine TimkoCenter for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, CA, 94025 USA; Department of Psychiatry and Behavioral Sciences, Stanford University, 401 N. Quarry Road, MC: 5717, Stanford, CA 94035 USA.
Todd H WagnerCenter for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, CA, 94025 USA; Department of Surgery, Stanford University School of Medicine, 291 Campus Drive, Li Ka Shing Building, Stanford, CA, 94305 USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS UG1 DA015815
6 · The paper itself

Abstract

background12 step mutual help groups are widely accessed by people with drug use disorder but infrequently subjected to rigorous evaluation. Pooling randomized trials containing a condition in which mutual help group attendance is actively facilitated presents an opportunity to assess the effectiveness of 12 step groups in large, diverse samples of drug use disorder patients.

methodsData from six federally-funded randomized trials were pooled (n = 1730) and subjected to two-stage instrumental variables modelling, and, fixed and random effects regression models. All trials included a 12 step group facilitation condition and employed the Addiction Severity Index as a core measure.

resultsThe ability of 12 step facilitation to increase mutual help group participation among drug use disorder patients was minimal, limiting ability to employ two-stage instrumental variable models that correct for selection bias. However, traditional fixed and random effect regression models found that greater 12 step mutual help group attendance by drug use disorder patients predicted reduced use of and problems with illicit drugs and also with alcohol.

conclusionFacilitating significant and lasting involvement in 12 step groups may be more challenging for drug use disorder patients than for alcohol use disorder patients, which has important implications for clinical work and for effectiveness evaluations. Though selection bias could explain part of the results of traditional regression models, the finding that participation in 12 step mutual help groups predicts lower illicit drug and alcohol use and problems in a large, diverse, sample of drug use disorder patients is encouraging.

Indexed as

Self-Help GroupsAdultAlcohol DrinkingAlcoholismClinical Trials as TopicHumansMaleMiddle AgedSelection BiasSubstance-Related Disorders12 stepsContinuing careMutual help groupsOpioid addictionRecoverySelf-help

Identifiers

PMID32801112
PMCPMC7502458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.