Evidence map›Paper›PMID 32800992›Full record

ArticleNeuroImage2020

Keep it real: rethinking the primacy of experimental control in cognitive neuroscience.

Samuel A Nastase, Ariel Goldstein, Uri Hasson

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Review
  6. From seeing to showing: towards a neuroscience of emotion production.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  7. Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder.medRxiv : the preprint server for health sciences · 2026
    Article
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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel A NastasePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. Electronic address: sam.nastase@gmail.com.
Ariel GoldsteinPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Uri HassonPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA; Department of Psychology, Princeton University, Princeton, NJ, USA.

Funding

Speaker-listener coupling: a novel neural approach for assessing communicationDP1HD091948 · NICHD · PRINCETON UNIVERSITY · PI HASSON, URI · 2016 to 2021
$5.6M
Brain-to-brain dynamical Coupling: A New framework for the communication of social knowledgeR01MH112566 · NIMH · PRINCETON UNIVERSITY · PI HASSON, URI, WHEATLEY, THALIA P · 2017 to 2021
$2.5M
NICHD NIH HHS DP1 HD091948NIMH NIH HHS R01 MH112566
6 · The paper itself

Abstract

Naturalistic experimental paradigms in neuroimaging arose from a pressure to test the validity of models we derive from highly-controlled experiments in real-world contexts. In many cases, however, such efforts led to the realization that models developed under particular experimental manipulations failed to capture much variance outside the context of that manipulation. The critique of non-naturalistic experiments is not a recent development; it echoes a persistent and subversive thread in the history of modern psychology. The brain has evolved to guide behavior in a multidimensional world with many interacting variables. The assumption that artificially decoupling and manipulating these variables will lead to a satisfactory understanding of the brain may be untenable. We develop an argument for the primacy of naturalistic paradigms, and point to recent developments in machine learning as an example of the transformative power of relinquishing control. Naturalistic paradigms should not be deployed as an afterthought if we hope to build models of brain and behavior that extend beyond the laboratory into the real world.

Indexed as

Cognitive NeuroscienceMachine LearningBrainCognitionHumansNeuroimagingEcological psychologyEcological validityExperimental designGeneralizabilityNaturalistic stimuliRepresentative design

Identifiers

PMID32800992
PMCPMC7789034

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.