SynthesisJournal of ethnopharmacology2021
A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum.
Synthesis in Journal of ethnopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 94 citations in OpenAlex.
- Organ Identity Outweighs Geographic Origin in Shaping the Metabolome ofMetabolites · 2026Article
- Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular Mechanistic Pathways Targeted by Natural Products in the Prevention and Treatment of Alcoholic Liver Disease.Life (Basel, Switzerland) · 2026Review
- Assembly and comparative analysis of the complete mitochondrial genome of Tetrastigma Hemsleyanum Diels & Gilg: an invaluable traditional Chinese medicine.BMC plant biology · 2026Article
- A comprehensive analysis of nutritional, phytochemical, and antioxidant benefits of an underutilized fruit Tetrastigma leucostaphylum.Scientific reports · 2025Article
- The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC.OncoTargets and therapy · 2025Review
- Abiotic stress-induced changes in Tetrastigma hemsleyanum: insights from secondary metabolite biosynthesis and enhancement of plant defense mechanisms.BMC plant biology · 2024Article
- Differential effects of winter cold stress on soil bacterial communities, metabolites, and physicochemical properties in two varieties ofMicrobiology spectrum · 2024Article
- Full-length transcriptome reveals the pivotal role of ABA and ethylene in the cold stress response ofFrontiers in plant science · 2024Article
- Effects of UV-A/B/C on flavonoids and related synthetic enzymes inFrontiers in plant science · 2024Article
- Insights into Metabolic Engineering of Bioactive Molecules inCurrent genomics · 2023Review
- Optimization of tetrastigma hemsleyanum extraction process based on GA-BPNN model and analysis of its antioxidant effect.Heliyon · 2023Article
- Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials.Journal of pharmacopuncture · 2023Review
- Screening out Biomarkers ofMolecules (Basel, Switzerland) · 2023Article
- Phylogenetic Analysis ofBiomolecules · 2023Article
- Integrative Analysis of the Transcriptome and Metabolome Reveals the Developmental Mechanisms and Metabolite Biosynthesis of the Tuberous Roots ofMolecules (Basel, Switzerland) · 2023Article
- Gut microbiota and transcriptome profiling revealed the protective effect of aqueous extract ofCurrent research in food science · 2023Article
- Multi-omics combined with MALDI mass spectroscopy imaging reveals the mechanisms of biosynthesis of characteristic compounds inFrontiers in plant science · 2023Article
- Role of plant metabolites in the formation of bacterial communities in the rhizosphere ofFrontiers in microbiology · 2023Article
- Flavonoid Metabolism inMolecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ethnopharmacological relevanceTetrastigma hemsleyanum Diels et Gilg (T.hemsleyanum), a rare herbal plant distributed in subtropical areas of mainland China, has become a focus of scientific attention in recent years because of its high traditional value, including uses for treatment of children with fever, pneumonia, asthma, rheumatism, hepatitis, menstrual disorders, scrofula, and pharynx pain.
aimThis systematic review aims to provide an insightful understanding of traditional uses, chemical composition, pharmacological effect and clinical application of T. hemsleyanum, and lay a foundation for the further study and for the utilization of T. hemsleyanum resource. MATERIALS AND
methodsA domestic and overseas literature search in known databases was conducted for published articles using the relevant keywords.
resultsOne hundred and forty-two chemical constituents identified from T. hemsleyanum have been reported, including flavonoids, phenolic acids, polysaccharide, organic acids, fatty acids, terpenoids, steroids, amino acid and others. Among these components, flavonoids and polysaccharides were the representative active ingredients of T. hemsleyanum, which have been widely investigated. Modern pharmacological studies have shown that these components exhibited various pharmacological activities, such as anti-inflammatory, antioxidant, antivirus, antitumor, antipyretic, anti-hepatic injury, immunomodulatory, antibacterial etc. Moreover, different toxicological studies indicated that the clinical dosage of T. hemsleyanum was safe and reliable.
conclusionsModern pharmacological studies have well supported and clarified some traditional uses, and T. hemsleyanum has a good prospect for the development of new drugs due to these outstanding properties. However, the present findings did not provide an in-depth evaluation of bioactivity of the extracts, the composition of its active extracts was not clear. Moreover, they were insufficient to satisfactorily explain some mechanisms of action. Data regarding many aspects of T. hemsleyanum, such as links between the traditional uses and bioactivities, pharmacokinetics, quality control standard and the clinical value of active compositions is still limited which need more attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.