Trial reportThe Journal of pediatrics2020
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Trial report in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Experience in endoscope choice for neuroendoscopic lavage for intraventricular hemorrhage of prematurity: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Intervention at an early threshold for post-hemorrhagic ventricular dilatation in preterm infants: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Observed pre-intervention and non-intervention ventricular growth trajectories in neonates with severe intraventricular hemorrhage and post-hemorrhagic ventricular dilation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Acute Neurological Deterioration in a Child with Shunt-Dependent Post-Hemorrhagic Hydrocephalus: A Case Report.Children (Basel, Switzerland) · 2026Article
- Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants.Journal of clinical medicine · 2026Article
- Prolonged puncturing decreases ventriculoperitoneal shunt insertion rate in neonates with posthemorrhagic ventricular dilatation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Neuroprognostication in infants born preterm at the limits of viability: assessment under uncertainty.Pediatric research · 2026Review
- Early versus Late Ventricular Intervention Study (ELVIS) in post-hemorrhagic ventricular dilatation: Bayesian reanalysis of brain injury and outcomes.Pediatric research · 2026Article
- Wide variation in death rates and post-hemorrhagic hydrocephalus (PHH) treatment in preterm severe intraventricular hemorrhage (IVH).Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Post-hemorrhagic ventricular dilatation: Comparison of management pathways among North American level IV NICUs.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neurodevelopmental impairment in preterm infants following progressive post-hemorrhagic ventricular dilatation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Is there a role for cerebral NIRS in the management of post hemorrhagic ventricular dilation?Pediatric research · 2026Article
- Ventricular size on term magnetic resonance imaging in extremely preterm infants with and without germinal matrix-intraventricular haemorrhage.Pediatric radiology · 2026Article
- Impact of posthemorrhagic ventricular dilatation on cerebral oxygenation in preterm infants with intraventricular hemorrhage.Pediatric research · 2026Article
- Changes of head circumference and ventricular width in infant hydrocephalus managed with adjustable shunt valves and gravitational assistance-a comparative bi-center study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Neuroendoscopic lavage: a single-center retrospective cohort in the USA.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Use of standard assessment of post-hemorrhagic ventricular dilation to improve collaboration with referring centers.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Ventricular Subgaleal Shunt in Children Under Three Months of Age, from Diagnosis to Outcome: A Review After 11 Years of Experience in a French University Hospital.Children (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability. STUDY
designThis multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores <-2 SDs at 24 months corrected age.
resultsOutcomes were assessed in 113 of 126 infants. The composite adverse outcome was seen in 20 of 58 infants (35%) in the low threshold group and 28 of 55 (51%) in the high threshold (P = .07). The low threshold intervention was associated with a decreased risk of an adverse outcome after correcting for gestational age, severity of intraventricular hemorrhage, and cerebellar hemorrhage (aOR, 0.24; 95% CI, 0.07-0.87; P = .03). Infants with a favorable outcome had a smaller fronto-occipital horn ratio (crude mean difference, -0.06; 95% CI, -0.09 to -0.03; P < .001) at term-equivalent age. Infants in the low threshold group with a ventriculoperitoneal shunt, had cognitive and motor scores similar to those without (P = .3 for both), whereas in the high threshold group those with a ventriculoperitoneal shunt had significantly lower scores than those without a ventriculoperitoneal shunt (P = .01 and P = .004, respectively).
conclusionsIn a post hoc analysis, earlier intervention was associated with a lower odds of death or severe neurodevelopmental disability in preterm infants with progressive posthemorrhagic ventricular dilatation.
trial registrationISRCTN43171322.
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