Evidence map›Paper›PMID 32800702›Full record

ArticleAnalytical biochemistry2020

Fluorescent contact lens for continuous non-invasive measurements of sodium and chloride ion concentrations in tears.

Ramachandram Badugu, Henryk Szmacinski, E Albert Reece, Bennie H Jeng, Joseph R Lakowicz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
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  6. Lab-on-a-molecule and multi-analyte sensing.Frontiers in chemistry · 2024
    Review
  7. RSC advances · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ramachandram BaduguCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD, 21201, USA. Electronic address: rbadugu@som.umaryland.edu.
Henryk SzmacinskiCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD, 21201, USA.
E Albert ReeceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, Md, 21201, USA; Department of Medicine, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, Md, 21201, USA.
Bennie H JengDepartment of Ophthalmology & Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood Street, Baltimore, Md, 21201, USA.
Joseph R LakowiczCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD, 21201, USA. Electronic address: jlakowicz@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Coupled Emission Microscopy for the BiosciencesR01GM125976 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2018 to 2021
$1.8M
Diffusion-Enhanced Lanthanide Nanoparticle FRET AssaysR21GM107986 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2014 to 2016
$568k
Fluorescence Lifetime Imaging Microscopy (FLIM)S10RR026370 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2010 to 2010
$474k
Plasmon-coupled Fluorescence Correlation Spectroscopy in NanoholesR21GM129561 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2018 to 2019
$413k
Multi-User Time-Resolved Fluorescence SpectrometerS10OD019975 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2015
$243k
NCRR NIH HHS S10 RR026370NIGMS NIH HHS R01 GM125976NIGMS NIH HHS R21 GM107986NIGMS NIH HHS R21 GM129561NIH HHS S10 OD019975
6 · The paper itself

Abstract

Rapid and non-invasive measurement of hydration status is medically important because even mild levels of dehydration can have a significant impact on physical and cognitive performance. Despite the potential value of determining whole-body hydration based on the electrolytes found in tears, very few tests are available. An area of intense interest is the development of a contact lens which could measure ion concentrations in tears, specifically that of sodium (Na

Indexed as

Biosensing TechniquesBody WaterChloridesFluorescent DyesHumansHydrogelsHydrophobic and Hydrophilic InteractionsIonsOrganic ChemicalsPolylysineQuinolinesSiliconesSodiumSpectrometry, FluorescenceTearsWater6-methoxyquinolineChloridesFluorescent DyesHydrogelsIonsOrganic ChemicalsPolylysineQuinolinesSiliconesSodiumsodium greenWaterContact lensesDry eye diseaseElectrolytes in tearsFluorescence sensingHydrationTear composition

Identifiers

PMID32800702
PMCPMC7530058
OpenAlexW3048392529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.