ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2020
Drug induced pancreatitis is the leading known cause of first attack acute pancreatitis in children.
Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Admission risk factors and predictors of moderate or severe pediatric acute pancreatitis: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Drug-associated acute pancreatitis in paediatric versus adult reports: a disproportionality analysis using FAERS.European journal of pediatrics · 2026Article
- A lipid-immune network signature defines susceptibility to asparaginase-associated pancreatitis.JCI insight · 2026Article
- Article
- Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality.World journal of gastroenterology · 2025Article
- Clinical and imaging predictors for the development of diabetes mellitus following a single episode of acute pancreatitis in youth.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2025Article
- Liberal Fluid Resuscitation is Associated with Improved Outcomes in Pediatric Acute Pancreatitis.The Journal of pediatrics · 2025Observational
- The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Observational
- Nutritional parameters following first episode of pediatric acute pancreatitis.Clinical nutrition ESPEN · 2024Observational
- Pancreas volumes in pediatric patients following index acute pancreatitis and acute recurrent pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2024Article
- Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis.World journal of gastrointestinal endoscopy · 2023Article
- Current trends in acute pancreatitis: Diagnostic and therapeutic challenges.World journal of gastroenterology · 2023Review
- A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis.Science translational medicine · 2023Article
- High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis.Pediatric diabetes · 2023Article
- Acute Pancreatitis and Recurrent Acute Pancreatitis in Children: A 10-Year Retrospective Study.Gastroenterology research and practice · 2022Article
- Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis.PloS one · 2022Article
- A Practical Approach to Management of Acute Pancreatitis: Similarities and Dissimilarities of Disease in Children and Adults.Journal of clinical medicine · 2021Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesDrug induced acute pancreatitis (DIAP) as one of the acute pancreatitis (AP) risks factors is a poorly understood entity. The aim of the current study was to compare the characteristics and course of DIAP cases in children presenting with a first attack of AP.
methodsPatients presenting with AP were included in a prospective database. We enrolled 165 AP patients that met criteria for inclusion. DIAP patients were included in that group if they were exposed to a drug known to be associated with AP and the rest were included in the non-drug induced-acute pancreatitis (non-DIAP) group.
resultsDIAP was observed in 40/165 (24%) of cases, 24 cases had drug-induced as the sole risk factor, and 16 had DIAP with another risk factor(s). The two groups were similar in intravenous fluid and feeding managements, but ERCP was more commonly performed in the non- DIAP group, 14 (11%), vs 0% in the DIAP group, p = 0.02. Moderately severe [9 (23%) vs 11 (9%)] and severe AP [7 (18%) vs 6 (5%)] were more commonly associated with DIAP than non- DIAP, p = 0.001. DIAP was more commonly associated with ICU stay, 10 (25%), vs 12 (10%), p = 0.01, hospital stay was longer in DIAP median (IQR) of 6 (3.9-11) days vs 3.3 (2-5.7) days in non- DIAP, p = 0.001. The DIAP group had a significantly higher proportion of comorbidities (p < 0.0001).
conclusionsDIAP is a leading risk factor for a first attack of AP in children and is associated with increased morbidity and severity of the pancreatitis course. DIAP warrants further investigation in future studies.
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