ArticleBritish journal of anaesthesia2020
Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations.
Article in British journal of anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02275026 (Trajectory of Recovery in the Elderly), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trajectory of Recovery in the Elderly
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Putative Mechanisms of Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Examined Using Magnetic Resonance Imaging.Biological psychiatry global open science · 2025Article
- Imaging and Anesthesia Protocol Optimization in Sedated Clinical Resting-State fMRI.AJNR. American journal of neuroradiology · 2025Article
- Identification of brain-like complex information architectures in embryonic tissue ofCommunicative & integrative biology · 2025Article
- Characteristic dynamic functional connectivity during sevoflurane-induced general anesthesia.Scientific reports · 2023Article
- Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- [A Clinical Study of Patients with Primary Parkinson's Disease Undergoing Bilateral Deep Brain Stimulation (STN-DBS) Surgery in the Subthalamic Nucleus under General Anesthesia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- Neuroinflammation in perioperative neurocognitive disorders: From bench to the bedside.CNS neuroscience & therapeutics · 2022Review
- Functional network antagonism and consciousness.Network neuroscience (Cambridge, Mass.) · 2022Article
- Lateralisation of subcortical functional connectivity during and after general anaesthesia.British journal of anaesthesia · 2022Article
- Structural and functional connectivity of the ascending arousal network for prediction of outcome in patients with acute disorders of consciousness.Scientific reports · 2021Article
- Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.Human brain mapping · 2021Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- High Multiband Acceleration Degrades Resting-State Functional MRI Reliability and Signal Quality Under Anesthesia.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundA growing body of literature addresses the possible long-term cognitive effects of anaesthetics, but no study has delineated the normal trajectory of neural recovery attributable to anaesthesia alone in adults. We obtained resting-state functional MRI scans on 72 healthy human volunteers between ages 40 and 80 (median: 59) yr before, during, and after general anaesthesia with sevoflurane, in the absence of surgery, as part of a larger study on cognitive function postanaesthesia.
methodsRegion-of-interest analysis, independent component analysis, and seed-to-voxel analysis were used to characterise resting-state functional connectivity and to differentiate between correlated and anticorrelated connectivity before, during, and after general anaesthesia.
resultsWhilst positively correlated functional connectivity remained essentially unchanged across these perianaesthetic states, anticorrelated functional connectivity decreased globally by 35% 1 h after emergence from general anaesthesia compared with baseline, as seen by the region-of-interest analysis. This decrease corresponded to a consistent reduction in expression of canonical resting-state networks, as seen by independent component analysis. All measures returned to baseline 1 day later.
conclusionsThe normal perianaesthesia trajectory of resting-state connectivity in healthy adults is characterised by a transient global reduction in anticorrelated activity shortly after emergence from anaesthesia that returns to baseline by the following day. CLINICAL
trial registrationNCT02275026.
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