Evidence map›Paper›PMID 32800244›Full record

ReviewEcotoxicology and environmental safety2020

Larval zebrafish as an in vitro model for evaluating toxicological effects of mycotoxins.

Ana Juan-García, Marie-Abèle Bind, Florian Engert

Open access · greenAbstract readReview
In one paragraph

Review in Ecotoxicology and environmental safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Comparative Assessment of Beeswax Alcohol and Coenzyme QPharmaceuticals (Basel, Switzerland) · 2024
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  5. Article
  6. Comparison of the In Vivo Efficacy of Cuban (RaydelPharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Consumption of Policosanol (RaydelPharmaceuticals (Basel, Switzerland) · 2023
    Article
  8. Interaction of Fumonisin B1,Biomolecules · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Evaluation of the Multimycotoxin-Degrading Efficiency ofInternational journal of molecular sciences · 2021
    Article
  13. In silico methods for metabolomic and toxicity prediction of zearalenone, α-zearalenone and β-zearalenone.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Ana Juan-GarcíaLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés S/n, 46100, Burjassot, València, Spain; Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA, USA. Electronic address: ana.juan@uv.es.
Marie-Abèle BindDepartment of Statistics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA.
Florian EngertDepartment of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA, USA.
Harvard University · US

Funding

Transporting established insights from classical experimental design to address causal questions in environmental epidemiology including the understanding of biological mediating mechanismsDP5OD021412 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIND, MARIE-ABELE CATHERINE · 2016 to 2020
$2.1M
NIH HHS DP5 OD021412
6 · The paper itself

Abstract

The presence of mycotoxins in food has created concern. Mycotoxin prevalence in our environment has changed in the last few years maybe due to climatic and other environmental changes. Evidence has emerged from in vitro and in vivo models: some mycotoxins have been found to be potentially carcinogenic, embryogenically harmful, teratogenic, and to generate nephrotoxicity. The risk assessment of exposures to mycotoxins at early life stages became mandatory. In this regard, the effects of toxic compounds on zebrafish have been widely studied, and more recently, mycotoxins have been tested with respect to their effects on developmental and teratogenic effects in this model system, which offers several advantages as it is an inexpensive and an accessible vertebrate model to study developmental toxicity. External post-fertilization and quick maturation make it sensitive to environmental effects and facilitate the detection of endpoints such as morphological deformities, time of hatching, and behavioral responses. Therefore, there is a potential for larval zebrafish to provide new insights into the toxicological effects of mycotoxins. We provide an overview of recent mycotoxin toxicological research in zebrafish embryos and larvae, highlighting its usefulness to toxicology and discuss the strengths and limitations of this model system.

Indexed as

ZebrafishAnimalsEmbryo, NonmammalianLarvaMycotoxinsTeratogensWater Pollutants, ChemicalMycotoxinsTeratogensWater Pollutants, ChemicalEmbryonic developmentEmbryosLarvaeMixturesModel systemMycotoxinsToxicologyZebrafish

Identifiers

PMID32800244
PMCPMC7431674
OpenAlexW3040995620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.