ArticleDevelopmental cell2020
Buckling of an Epithelium Growing under Spherical Confinement.
Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 117 citations in OpenAlex.
- Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development.Nature materials · 2026Article
- Cell assays in microcompartments driven by droplet microfluidics and hydrogel technologies.Journal of biochemistry · 2026Review
- A biohybrid system to reconstruct epithelial morphomechanicsMaterials today. Bio · 2026Article
- Article
- Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing.Nature communications · 2025Article
- A multi-tiered mechanical mechanism shapes the early neural plate.Nature communications · 2025Article
- Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis.Science advances · 2025Article
- Epithelial Layer Fluidization by Curvature-Induced Unjamming.Physical review letters · 2025Article
- Topology changes ofScience advances · 2025Article
- Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles.Current topics in developmental biology · 2025Review
- Mechanochemical bistability of intestinal organoids enables robust morphogenesis.Nature physics · 2025Article
- Deciphering the interplay between biology and physics with a finite element method-implemented vertex organoid model: A tool for the mechanical analysis of cell behavior on a spherical organoid shell.PLoS computational biology · 2025Article
- Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids.ACS applied bio materials · 2024Article
- Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model.Cell stem cell · 2024Article
- Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the Drosophila leg.Development (Cambridge, England) · 2024Article
- Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture.Nature cell biology · 2024Article
- Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization.Nature physics · 2024Article
- Forceful patterning: theoretical principles of mechanochemical pattern formation.EMBO reports · 2023Review
- Transducing compressive forces into cellular outputs in cancer and beyond.Life science alliance · 2023Review
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Many organs are formed through folding of an epithelium. This change in shape is usually attributed to tissue heterogeneities, for example, local apical contraction. In contrast, compressive stresses have been proposed to fold a homogeneous epithelium by buckling. While buckling is an appealing mechanism, demonstrating that it underlies folding requires measurement of the stress field and the material properties of the tissue, which are currently inaccessible in vivo. Here, we show that monolayers of identical cells proliferating on the inner surface of elastic spherical shells can spontaneously fold. By measuring the elastic deformation of the shell, we infer the forces acting within the monolayer and its elastic modulus. Using analytical and numerical theories linking forces to shape, we find that buckling quantitatively accounts for the shape changes of our monolayers. Our study shows that forces arising from epithelial growth in three-dimensional confinement are sufficient to drive folding by buckling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.