Trial reportJournal of neuroengineering and rehabilitation2020
Cortical priming strategies for gait training after stroke: a controlled, stratified trial.
Trial report in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03492229 (Cortical Priming to Optimize Gait Rehabilitation Post Stroke), which is not on this map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cortical Priming to Optimize Gait Rehabilitation Post Stroke
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effects of treadmill training combined with transcranial direct current stimulation on mobility, motor performance, balance function, and other brain-related outcomes in stroke survivors: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Non-invasive brain stimulation for the improvement of lower extremity motor function in patients with stroke: a systematic review and network meta-analysis.Frontiers in neurology · 2025Pooled it
- Enhancing functional motor outcomes in chronic stroke: A systematic review of the growing role of non-invasive brain stimulation.PloS one · 2025Pooled it
- Application of Neuromodulation Techniques in the Treatment of Proprioceptive Disorders After Stroke: A Meta-Analysis of Randomized Controlled Trials.Neural plasticity · 2025Pooled it
- Non-invasive brain stimulation for improving gait, balance, and lower limbs motor function in stroke.Journal of neuroengineering and rehabilitation · 2022Pooled it
- Transcranial direct current stimulation for gait recovery following stroke: A systematic review of current literature and beyond.Frontiers in neurology · 2022Pooled it
- The Effects of Transcranial Direct Current Stimulation on Balance and Gait in Stroke Patients: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Trial
- High-Intensity Gait Training With Functional Electrical Stimulation Enhances Corticospinal Excitability of Paretic Ankle Muscles in Individuals Post-Stroke.Neural plasticity · 2025Trial
- Association of Interhemispheric Structural Integrity With Transcallosal Interhemispheric Inhibition in People With Chronic Stroke.Journal of neuroscience research · 2026Article
- Harnessing Neuroplasticity: The Role of Priming in Enhancing Post Stroke Motor Function.Restorative neurology and neuroscience · 2026Review
- Tailoring interval training in stroke rehabilitation: The role of peak velocity.Journal of rehabilitation research and practice · 2025Article
- Measuring Neuroplasticity in Response to Cardiovascular Exercise in People With Stroke: A Critical Perspective.Neurorehabilitation and neural repair · 2024Article
- Barriers to Enrollment in a Post-Stroke Neuromodulation and Walking Study: Implications for Recruiting Women.Neurorehabilitation and neural repair · 2024Article
- The effects of combined transcranial brain stimulation and a 4-week visuomotor stepping training on voluntary step initiation in persons with chronic stroke-a pilot study.Frontiers in neurology · 2024Article
- Chronic Functional Adaptations Induced by the Application of Transcranial Direct Current Stimulation Combined with Exercise Programs: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2023Review
- Non-paretic leg movements can facilitate cortical drive to the paretic leg in individuals post stroke with severe motor impairment: Implications for motor priming.The European journal of neuroscience · 2023Article
- Functional connectivity of proximal and distal lower limb muscles and impact on gait variability in stroke.Gait & posture · 2023Article
- Understanding factors contributing to participant satisfaction in stroke walking recovery clinical trials.Contemporary clinical trials communications · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStroke survivors experience chronic gait impairments, so rehabilitation has focused on restoring ambulatory capacity. High-intensity speed-based treadmill training (HISTT) is one form of walking rehabilitation that can improve walking, but its effectiveness has not been thoroughly investigated. Additionally, cortical priming with transcranial direct current stimulation (tDCS) and movement may enhance HISTT-induced improvements in walking, but there have been no systematic investigations. The objective of this study was to determine if motor priming can augment the effects of HISTT on walking in chronic stroke survivors.
methodsEighty-one chronic stroke survivors participated in a controlled trial with stratification into four groups: 1) control-15 min of rest (n = 20), 2) tDCS-15 min of stimulation-based priming with transcranial direct current stimulation (n = 21), 3) ankle motor tracking (AMT)-15 min of movement-based priming with targeted movements of the ankle and sham tDCS (n = 20), and 4) tDCS+AMT-15 min of concurrent tDCS and AMT (n = 20). Participants performed 12 sessions of HISTT (40 min/day, 3 days/week, 4 weeks). Primary outcome measure was walking speed. Secondary outcome measures included corticomotor excitability (CME). Outcomes were measured at pre, post, and 3-month follow-up assessments.
resultsHISTT improved walking speed for all groups, which was partially maintained 3 months after training. No significant difference in walking speed was seen between groups. The tDCS+AMT group demonstrated greater changes in CME than other groups. Individuals who demonstrated up-regulation of CME after tDCS increased walking speed more than down-regulators.
conclusionsOur results support the effectiveness of HISTT to improve walking; however, motor priming did not lead to additional improvements. Upregulation of CME in the tDCS+AMT group supports a potential role for priming in enhancing neural plasticity. Greater changes in walking were seen in tDCS up-regulators, suggesting that responsiveness to tDCS might play an important role in determining the capacity to respond to priming and HISTT.
trial registrationClinicalTrials.gov , NCT03492229. Registered 10 April 2018 - retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03492229 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.