Evidence map›Paper›PMID 32799841›Full record

Trial reportBMC pediatrics2020

The efficacy and safety of peripheral intravenous parenteral nutrition vs 10% glucose in preterm infants born 30 to 33 weeks' gestation: a randomised controlled trial.

Hiroki Suganuma, Dennis Bonney, Chad C Andersen, Andrew J McPhee, Thomas R Sullivan, Robert A Gibson, Carmel T Collins

Open access · goldAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hiroki SuganumaSAHMRI Women and Kids, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Dennis BonneyNeonatal Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.
Chad C AndersenNeonatal Medicine, Women's and Children's Hospital, Adelaide, SA, Australia.
Andrew J McPheeSAHMRI Women and Kids, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Thomas R SullivanSAHMRI Women and Kids, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Robert A GibsonSAHMRI Women and Kids, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia.
Carmel T CollinsSAHMRI Women and Kids, South Australian Health and Medical Research Institute Adelaide, South Australia, Australia. carmel.collins@sahmri.com.ORCID 0000-0003-3308-9948
South Australian Health and Medical Research Institute · AUWomen's and Children's Hospital · AU

Funding

National Health and Medical Research Council (AU) APP1046207National Health and Medical Research Council (AU) APP1132596
6 · The paper itself

Abstract

backgroundPreterm infants born 30 to 33 weeks' gestation often require early support with intravenous fluids because of respiratory distress, hypoglycemia or feed intolerance. When full feeds are anticipated to be reached within the first week, risks associated with intravenous delivery mode and type must be carefully considered. Recommendations are for parenteral nutrition to be infused via central venous lines (because of the high osmolarity), however, given the risks associated with central lines, clinicians may opt for 10% glucose via peripheral venous catheter when the need is short-term. We therefore compare a low osmolarity peripheral intravenous parenteral nutrition (P-PN) solution with peripheral intravenous 10% glucose on growth rate in preterm infants born 30 to 33 weeks' gestation.

methodsIn this parallel group, single centre, superiority, non-blinded, randomised controlled trial, 92 (P-PN 42, control 50) infants born 30

resultsThe rate of weight gain was significantly increased in P-PN infants compared with control (P-PN, n = 42, 18.7, SD 6.6 g/d vs control, n = 50, 14.8, SD 6.0 g/d; adjusted mean difference 3.9 g/d, 95% CI 1.3 to 6.6; P = 0.004), with the effect maintained to discharge home. Days to regain birthweight were significantly reduced and length gain significantly increased in P-PN infants. One infant in the P-PN group had a stage 3 extravasation which rapidly resolved. Blood urea nitrogen and triglyceride levels were significantly higher in the P-PN group in the first week of life, but there were no instances of abnormally high levels. There were no significant differences in any other clinical or biochemical outcomes.

conclusionP-PN improves the rate of weight gain to discharge home in preterm infants born 30 to 33 weeks gestation compared with peripheral intravenous 10% glucose.

trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12616000925448 . Registered 12 July 2016.

Indexed as

GlucoseInfant, PrematureAustraliaFemaleFish OilsHumansInfantInfant, NewbornOlive OilParenteral NutritionPregnancySoybean OilTriglyceridesFish OilsGlucoseOlive OilSMOFlipidSoybean OilTriglyceridesIntravenous lipidsParenteral nutritionPreterm infant

Identifiers

PMID32799841
PMCPMC7429781
OpenAlexW3049047921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.