Evidence map›Paper›PMID 32799840›Full record

ArticleBMC musculoskeletal disorders2020

Circulating neutrophil-to-lymphocyte ratio at admission predicts the long-term outcome in acute traumatic cervical spinal cord injury patients.

Jian-Lan Zhao, Song-Tao Lai, Zhuo-Ying Du, Jian Xu, Yi-Rui Sun, Qiang Yuan, Xing Wu, Zhi-Qi Li, Jin Hu, Rong Xie

Abstract read
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In one paragraph

Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Prognostic value of the systemic inflammatory index (SII) and systemic inflammatory response index (SIRI) in patients with traumatic spinal cord injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
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  16. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jian-Lan ZhaoDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Song-Tao LaiDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhuo-Ying DuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Jian XuDepartment of General Surgery, the Seventh Affiliated Hospital, SUN Yat-sen University, Shenzhen, 518000, China.
Yi-Rui SunDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Qiang YuanDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Xing WuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Zhi-Qi LiDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China.
Jin HuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China. 286644104@qq.com.
Rong XieDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Road (M), Shanghai, 200040, P.R. China. rongxie@fudan.edu.cn.

Funding

Foundation of Shanghai Municipal Commission of Health and Family Planning 201801075Foundation of Shanghai Municipal Commission of Health and Family Planning 201840063National Natural Science Foundation of China 81171133National Natural Science Foundation of China 81271375National Natural Science Foundation of China 81471241National Natural Science Foundation of China 81571111National Natural Science Foundation of China 81671200National Natural Science Foundation of China 81701206National Natural Science Foundation of China 81870909National Natural Science Foundation of China 81870968Public Medical Artificial Intelligence Training Platform XX-RGZN-01-17-4684Science and Technology Commission of Shanghai Municipality 16411955300Science and Technology Commission of Shanghai Municipality 18441903300Science and Technology Commission of Shanghai Municipality 18695841300Shanghai Minhang Science and Technology Commission 2018MHZ001The Major and Develop Project of Chinese Ministry of Science and Technology 2017ZX09304005
6 · The paper itself

Abstract

backgroundThe prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.

methodsWe performed a single-center retrospective cohort study to evaluate the prognostic value of NLR from peripheral whole blood count in patients with acute cervical tSCI. Patients within 6 h of acute cervical tSCI treated between Dec 2008 and May 2018 in Huashan Hospital of Fudan University were enrolled. Outcomes of patients with tSCI were assessed using American spinal injury association Impairment Scale (AIS). 6-month outcomes were dichotomized into poor outcome group (AIS A to C) and good outcome group (AIS D and E). Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Two prediction models based on admission characteristics were built to evaluate the prognostic value of NLR. The discriminative ability of predictive models was evaluated using the area under the curve (AUC).

resultsA total of 377 patients were identified from our single center in China PR. Multivariate analysis showed that age, AIS grade at admission, NLR (p < 0.001) and coagulopathy (p = 0.003) were independent predictors of the 6-months outcome for acute cervical tSCI patients. The model combing NLR and standard variables (AUC = 0.944; 95% CI, 0.923-0.964) showed a more favorable prognostic value than that without NLR (AUC = 0.841; 95% CI, 0.798-0.885) in terms of 6-month outcome.

conclusionsNLR is firstly identified as an independent predictor of the 6-month outcome in acute cervical tSCI patients worldwide. The prognostic value of NLR is favorable, and a high NLR is associated with poor outcome in patients with acute cervical tSCI.

Indexed as

Cervical CordSpinal Cord InjuriesChinaHumansInfant, NewbornLymphocytesNeutrophilsRetrospective Studies6-months outcomeAcute traumatic cervical spinal cord injuryNeutrophil-to-lymphocyte ratioPrediction modelPrognostic value

Identifiers

PMID32799840
PMCPMC7429795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.