ArticleBMC neurology2020
Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Choroid plexus enlargement correlates with cognitive dysfunction and disease progression in Moyamoya disease.Neurosurgical review · 2025Article
- Cognitive characteristics and ischemic prognosis of quantitative white matter hyperintensities in adult moyamoya disease.Communications medicine · 2025Article
- Glymphatic Impairment Associated with Neurocognitive Dysfunction in Moyamoya Disease.Translational stroke research · 2025Article
- The Role of Immune Cells in Moyamoya Disease.Brain sciences · 2025Review
- Whole-brain volumetric analysis in adult Moyamoya patients reveals significant atrophy compared to healthy controls.Brain communications · 2025Article
- Cognitive dysfunction in Moyamoya disease: latest developments and future directions.Frontiers in human neuroscience · 2024Review
- Neuropsychiatric Symptoms of Moyamoya Disease: Considerations for the Clinician.Neuropsychiatric disease and treatment · 2024Review
- Characteristics and Clinical Implication of White Matter Lesions in Patients With Adult Moyamoya Disease.Neurology · 2023Article
- Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association between White Matter Hyperintensities Burden and Cognitive Function in Adult Asymptomatic Moyamoya Disease.Journal of clinical medicine · 2023Article
- Application of DTI and fMRI in moyamoya disease.Frontiers in neurology · 2022Review
- Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy.Frontiers in neuroscience · 2022Article
- Progression in Moyamoya Disease: Clinical Features, Neuroimaging Evaluation, and Treatment.Current neuropharmacology · 2022Review
- Changes of cerebral cortical structure and cognitive dysfunction in "healthy hemisphere" after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease.BMC neuroscience · 2021Article
- Common genetic variation influencing human white matter microstructure.Science (New York, N.Y.) · 2021Article
- Non-invasive assessment of glymphatic dysfunction in middle cerebral artery stenosis based on DTI-ALPS and ro-ALPS.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIschemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determined.
methodsWe analyzed 12 patients with Moyamoya disease and 12 controls. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scans. The diffusion tensor imaging (DTI) data was processed using Tract-Based Spatial Statistics (TBSS). Significantly different white matter areas were correlated with different cognitive functions.
resultsThere were significant differences in intelligence and subtraction between the patients and controls (p < 0.05). The parameters of DTI such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) have different changes in anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), inferior longitudinal fasciculus, forceps minor, and other regions between the two groups.
conclusionLeft UF and IFO may be the key brain regions affecting arithmetic function, while bilateral IFO has an effect on intelligence. RD and AD may be better indicators for early prediction of chronic white matter damage than FA, while MD tends to have a comprehensive indirect change. There is cognitive impairment in ischemic MMD, which is closely related to white matter impairment.
trial registrationClinical Trial Registration, Unique identifier: ChiCTR1900023610 . Registered 4 June 2019 - Prospective study registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.