ReviewOrganogenesis2020
Recent Advances in Biomaterials for the Treatment of Bone Defects.
Review in Organogenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Berberine-Loaded Mesoporous Bioactive Glass Enhances Bone Repair through Combined Immunomodulatory and Osteogenic Effects.ACS omega · 2026Article
- Unidirectional porous beta-tricalcium phosphate supports three-dimensional osteogenic differentiation of human iPS cells without surface coating.Bone reports · 2026Article
- Article
- Degradable piezoelectric KNN/PLLA nanofibers for promoting osteogenesis and angiogenesis in bone regeneration.Biomedical engineering online · 2026Article
- Synergistic Regeneration of Osteoporotic Bone Defects Using PBM, Stem Cells, and hMPMS Scaffolds Via the miR-21/RUNX2 Axis.Cell biochemistry and biophysics · 2026Article
- Physicochemical Characterization, Cytotoxicity, and In Vivo Evaluation of a Hydroxyapatite-Silver Composite for Bone Regeneration.BioMed research international · 2026Article
- Quercetin in bone regeneration: optimization of drug delivery system and study of its synergistic mechanism with bone tissue engineering.Frontiers in pharmacology · 2026Review
- Temporal Trends and Projected Burden of Bone and Articular Cartilage Malignancies in East Asia: A Systematic Analysis for the Global Burden of Disease Study 2023.Orthopedic research and reviews · 2026Article
- Treatment of femoral defects in rats with collagen and elastin polymers combined with hydroxyapatite and bone morphogenetic protein.Frontiers in bioengineering and biotechnology · 2026Article
- Development and Evaluation of Scaffolds Based on Perch Collagen-Hydroxyapatite for Advanced Synthetic Bone Substitutes.Pharmaceutics · 2025Article
- Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration.Journal of Zhejiang University. Science. B · 2025Article
- Biofunctionalization of Stem Cell Scaffold for Osteogenesis and Bone Regeneration.Biomolecules · 2025Review
- The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice.Organogenesis · 2025Article
- Enhancing Radiopacity and Antibacterial Activity of Osteogenic Calcium Silicate Cement by Incorporating Strontium.Journal of functional biomaterials · 2025Article
- Article
- Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration.Bioactive materials · 2025Article
- Bone Regeneration: A Review of Current Treatment Strategies.Journal of clinical medicine · 2025Review
- Functionalized GelMA/CMCS Composite Hydrogel Incorporating Magnesium Phosphate Cement for Bone Regeneration.Biomedicines · 2025Article
- Emerging Strategies for Bioactive Agent-Loaded Xenogeneic Bone Scaffolds in Regenerative Medicine: A Comprehensive Review.Drug design, development and therapy · 2025Review
- Bone Regenerative Effect of Injectable Hypoxia Preconditioned Serum-Fibrin (HPS-F) in an Ex Vivo Bone Defect Model.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defects or fractures generally heal in the absence of major interventions due to the high regenerative capacity of bone tissue. However, in situations of severe/large bone defects, these orchestrated regeneration mechanisms are impaired. With advances in modern medicine, natural and synthetic bio-scaffolds from bioceramics and polymers that support bone growth have emerged and gained intense research interest. In particular, scaffolds that recapitulate the molecular cues of extracellular signals, particularly growth factors, offer potential as therapeutic bone biomaterials. The current challenges for these therapies include the ability to engineer materials that mimic the biological and mechanical properties of the real bone tissue matrix, whilst simultaneously supporting bone vascularization. In this review, we discuss the very recent innovative strategies in bone biomaterial technology, including those of endogenous biomaterials and cell/drug delivery systems that promote bone regeneration. We present our understanding of their current value and efficacy, and the future perspectives for bone regenerative medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.