ArticleJournal of intensive care medicine2021
Variation in SOFA (Sequential Organ Failure Assessment) Score Performance in Different Infectious States.
Article in Journal of intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A combined model based on lactate clearance rate and SOFA score in prognostic assessment of patients with severe pneumonia.BMC immunology · 2026Article
- From microbial dynamics to risk prediction: a nomogram-based model for hospital-acquired infections in rehabilitation settings.Frontiers in cellular and infection microbiology · 2026Article
- Article
- Review
- A framework and analytical exploration for a data-driven update of the Sequential Organ Failure Assessment (SOFA) score in sepsis.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Development and validation of mortality risk prediction model for sepsis secondary to pneumonia at intensive care unit admission: a retrospective case-cohort study.Frontiers in medicine · 2025Article
- Article
- A nomogram to predict 28-day mortality in patients with sepsis combined coronary artery disease: retrospective study based on the MIMIC-III database.Frontiers in medicine · 2024Article
- The Clinical Utility of Albumin with Sequential Organ Failure Assessment (SOFA) in Improving 30-Day Mortality Prediction in Patients with Infection in the Emergency Department.Journal of clinical medicine · 2023Article
- Explainable machine learning using perioperative serial laboratory results to predict postoperative mortality in patients with peritonitis-induced sepsis.Annals of surgical treatment and research · 2023Article
- Changing trend of neonatal Ca/P/Mg status in a Chinese population.Translational pediatrics · 2023Article
- Predictors and nomogram of in-hospital mortality in sepsis-induced myocardial injury: a retrospective cohort study.BMC anesthesiology · 2023Article
- Machine learning models for prediction of invasion Klebsiella pneumoniae liver abscess syndrome in diabetes mellitus: a singled centered retrospective study.BMC infectious diseases · 2023Article
- Viral load and disease severity in COVID-19.Internal and emergency medicine · 2022Observational
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8 authors.
Funding
Abstract
introductionIn this study, we investigated whether the Sequential Organ Failure Assessment (SOFA) score performance differs based on the type of infection among patients admitted to the intensive care unit (ICU) with infection. MATERIALS AND
methodsSingle-center, retrospective study of adult ICU patients admitted with infection between January 2008 and April 2018 at an urban tertiary care center. Patients were uniquely classified into different infection types based on International Classification of Diseases, Ninth Revision (
resultsA total of 12 283 patients were included. Of these, 50.6% were female and the median age was 70 years (interquartile range: 57-82). The most common infection types were pneumonia (32.2%) and UTI (31.0%). Overall, 1703 (13.9%) patients died prior to hospital discharge. The median baseline SOFA score (within 24 hours of ICU admission) for the cohort was 5 (3-8). Patients with peritonitis had the highest median SOFA score, 7 (4-9), and patients with cellulitis and UTI had the lowest median SOFA score, 4 (2-7). The SOFA score discrimination to predict mortality was highest among patients with endocarditis (area under the receiver operating characteristic [AUC]: 0.79, 95% CI: 0.69-0.90) and lowest for patients with isolated bacteremia (AUC: 0.59, 95% CI: 0.49-0.70). Observed mortality by quartile of SOFA score differed substantially across infection types.
conclusionsType of infection is an important consideration when interpreting the SOFA score. This is relevant as SOFA emerges as an important tool in the definition and prognostication of sepsis.
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