ArticleActa paediatrica (Oslo, Norway : 1992)2021
Cystatin C: A more reliable biomarker of renal function in young infants? A longitudinal cohort study.
Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Prognostic value of cystatin C for chronic kidney disease in pediatric urologic malformations.Pediatric research · 2026Article
- The relationship between maternal health during pregnancy and infant kidney development: a prospective cohort study.Journal of nephrology · 2024Article
- Current State of Pediatric Reference Intervals and the Importance of Correctly Describing the Biochemistry of Child Development: A Review.JAMA pediatrics · 2022Review
- Elevated Levels of Urinary Biomarkers TIMP-2 and IGFBP-7 Predict Acute Kidney Injury in Neonates after Congenital Heart Surgery.Journal of pediatric intensive care · 2022Article
- Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia: A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Cystatin C: A more reliable biomarker of renal function in young infants? A longitudinal cohort study.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe carried out a longitudinal cohort study to measure serial CysC (Cystatin C) in a cohort of neonates born preterm until the age of 2 years. We hypothesised that CysC levels are independent of body weight and would not vary with gestational age.
methodsThis prospective cohort study was conducted from August 2014 until October 2016, and follow-up was completed in October 2018. Preterm infants at less than 28 weeks of gestation (extremely preterm infants) were recruited and followed up until the age of 24 months. Blood samples for measurement of CysC were collected at regular intervals.
resultsWe recruited 58 preterm neonates with mean gestation was 26.2 (1.5) weeks, and a mean birth weight was 917 (140) g. One-way analysis of variance (ANOVA) did not show any significant difference in CysC levels between 28, 32 and 37 weeks' gestation (P = .09) despite a significant increase in body weight (P < .001). The mean CysC level was higher in the neonatal period and subsequently plateaued by 24 months.
conclusionSerum CysC level is independent of body weight and not influenced by postnatal age nor by gender.
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