Evidence map›Paper›PMID 32798678›Full record

ArticleNeuroImage2020

Intensity warping for multisite MRI harmonization.

J Wrobel, M L Martin, R Bakshi, P A Calabresi, M Elliot, D Roalf, R C Gur, R E Gur, R G Henry, G Nair and 12 more

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

J WrobelDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, USA. Electronic address: julia.wrobel@cuanschutz.edu.
M L MartinDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R BakshiLaboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
P A CalabresiDepartment of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M ElliotDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
D RoalfBrain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
R C GurDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA; Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Lifespan Brain Institute (LiBI) at the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
R E GurDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA; Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Lifespan Brain Institute (LiBI) at the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
R G HenryDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA.
G NairTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
J OhDepartment of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA; St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
N PapinuttoDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA.
D PelletierDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA.
D S ReichDepartment of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
W D RooneyAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.
T D SatterthwaiteBrain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
W SternDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA.
K PrabhakaranBrain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
N L SicotteDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
R T ShinoharaDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J GoldsmithDepartment of Biostatistics, Mailman School of Public Health, Columbia University, USA.
NAIMS CooperativeThe North American Imaging in Multiple Sclerosis (NAIMS) Cooperative.

Funding

Statistical Methods for Multilevel Multivariate Functional StudiesR01NS060910 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ciprian M Crainiceanu · 2009 to 2026
$8.3M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Ultra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8M
Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5M
Adaptive Large-Scale Framework for Automatic Biomedical Image SegmentationR01EB017255 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI YUSHKEVICH, PAUL A. · 2014 to 2018
$3.0M
Functional data analytics for kinematic assessments of motor controlR01NS097423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDSMITH, JEFF · 2016 to 2020
$1.8M
Statistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8M
Statistical methods for biosignals with varying domainsR01HL123407 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CRAINICEANU, CIPRIAN M · 2014 to 2017
$1.6M
Glutamate Chemical Exchange Saturation Transfer (GluCEST) Imaging in Cognitive AgingR56AG066656 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2020
$533k
Spatiotemporal Modeling of MRI Brain Lesion Trajectories of Biomarker DiscoveryR21NS093349 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ELOYAN, ANI, SHINOHARA, RUSSELL TAKESHI · 2016 to 2017
$454k
32-Channel Head Coil and Hardware Upgrade for 3T Magnetom Trio A Tim InstrumentS10OD016356 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2014 to 2014
$115k
NHLBI NIH HHS R01 HL123407NIA NIH HHS R56 AG066656NIBIB NIH HHS R01 EB017255NIH HHS S10 OD016356NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH119185NIMH NIH HHS R01 MH120174NINDS NIH HHS R01 NS060910NINDS NIH HHS R01 NS085211NINDS NIH HHS R01 NS097423NINDS NIH HHS R21 NS093349
6 · The paper itself

Abstract

In multisite neuroimaging studies there is often unwanted technical variation across scanners and sites. These "scanner effects" can hinder detection of biological features of interest, produce inconsistent results, and lead to spurious associations. We propose mica (multisite image harmonization by cumulative distribution function alignment), a tool to harmonize images taken on different scanners by identifying and removing within-subject scanner effects. Our goals in the present study were to (1) establish a method that removes scanner effects by leveraging multiple scans collected on the same subject, and, building on this, (2) develop a technique to quantify scanner effects in large multisite studies so these can be reduced as a preprocessing step. We illustrate scanner effects in a brain MRI study in which the same subject was measured twice on seven scanners, and assess our method's performance in a second study in which ten subjects were scanned on two machines. We found that unharmonized images were highly variable across site and scanner type, and our method effectively removed this variability by aligning intensity distributions. We further studied the ability to predict image harmonization results for a scan taken on an existing subject at a new site using cross-validation.

Indexed as

Magnetic Resonance ImagingAlgorithmsArtifactsBrainBrain MappingHumansImage Processing, Computer-AssistedMaleMiddle AgedReproducibility of ResultsElsarticle.clsImage harmonizationIntensity normalizationMultisite imagingWarping

Identifiers

PMID32798678
PMCPMC8412236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.