Evidence map›Paper›PMID 32798471›Full record

ArticleThe lancet. Diabetes & endocrinology2020

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study.

Naomi Holman, Peter Knighton, Partha Kar, Jackie O'Keefe, Matt Curley, Andy Weaver, Emma Barron, Chirag Bakhai, Kamlesh Khunti, Nicholas J Wareham and 3 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The lancet. Diabetes & endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06844227 (Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit), which is not on this map. Cited by 497 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
497citing papers in PubMed, 5 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06844227 recruitingnot on this mapstarted 2021, after this paper: background citation

Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual), a Simple Perioperative Anticoagulant Management Approach, Replacing a Resource-intensive In-person Doctor-patient Consultation, With a Simple Virtual Care Model That Will Provide a New Standard of Care for Patients on a Direct Oral Anticoagulant or Warfarin and Require Elective Surgery/Procedure.

TypeobservationalSponsorMcMaster UniversityRan2021 to 2026Enrolled1,780ConditionsAtrial Fibrillation (AF)
3 · Its place in the literature

Who cites it

497 citing papers in PubMed, 5 syntheses or guidelines pooled it, 931 citations in OpenAlex.

  1. Pooled it
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  3. Pediatric endocrinopathies related to COVID-19: an update.World journal of pediatrics : WJP · 2023
    Pooled it
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  6. Review
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  9. Banting memorial lecture 2025: Aligning clinical practice, policy and research.Diabetic medicine : a journal of the British Diabetic Association · 2026
    Article
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437 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Naomi HolmanNHS England and NHS Improvement, London, UK; NHS Digital, Leeds, UK; Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
Peter KnightonNHS Digital, Leeds, UK.
Partha KarNHS England and NHS Improvement, London, UK; Portsmouth Hospitals NHS Trust, Portsmouth, UK.
Jackie O'KeefeNHS Digital, Leeds, UK.
Matt CurleyNHS Digital, Leeds, UK.
Andy WeaverNHS England and NHS Improvement, London, UK.
Emma BarronPublic Health England, York, UK.
Chirag BakhaiNHS England and NHS Improvement, London, UK.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Naveed SattarInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
Bob YoungDiabetes UK, London, UK.
Jonathan ValabhjiNHS England and NHS Improvement, London, UK; Department of Diabetes and Endocrinology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK; Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK. Electronic address: jonathan.valabhji@nhs.net.
NHS Digital · GBNHS EnglandDiabetes UK · GBImperial College Healthcare NHS Trust · GBLeicester General Hospital · GBPortsmouth Hospitals NHS Trust · GBPublic Health England · GBUniversity of Cambridge · GBUniversity of Glasgow · GB

Funding

Medical Research Council MC_UU_12015/1
6 · The paper itself

Abstract

backgroundDiabetes has been associated with increased COVID-19-related mortality, but the association between modifiable risk factors, including hyperglycaemia and obesity, and COVID-19-related mortality among people with diabetes is unclear. We assessed associations between risk factors and COVID-19-related mortality in people with type 1 and type 2 diabetes.

methodsWe did a population-based cohort study of people with diagnosed diabetes who were registered with a general practice in England. National population data on people with type 1 and type 2 diabetes collated by the National Diabetes Audit were linked to mortality records collated by the Office for National Statistics from Jan 2, 2017, to May 11, 2020. We identified the weekly number of deaths in people with type 1 and type 2 diabetes during the first 19 weeks of 2020 and calculated the percentage change from the mean number of deaths for the corresponding weeks in 2017, 2018, and 2019. The associations between risk factors (including sex, age, ethnicity, socioeconomic deprivation, HbA

findingsWeekly death registrations in the first 19 weeks of 2020 exceeded the corresponding 3-year weekly averages for 2017-19 by 672 (50·9%) in people with type 1 diabetes and 16 071 (64·3%) in people with type 2 diabetes. Between Feb 16 and May 11, 2020, among 264 390 people with type 1 diabetes and 2 874 020 people with type 2 diabetes, 1604 people with type 1 diabetes and 36 291 people with type 2 diabetes died from all causes. Of these total deaths, 464 in people with type 1 diabetes and 10 525 in people with type 2 diabetes were defined as COVID-19 related, of which 289 (62·3%) and 5833 (55·4%), respectively, occurred in people with a history of cardiovascular disease or with renal impairment (eGFR <60 mL/min per 1·73 m

interpretationDeaths in people with type 1 and type 2 diabetes rose sharply during the initial COVID-19 pandemic in England. Increased COVID-19-related mortality was associated not only with cardiovascular and renal complications of diabetes but, independently, also with glycaemic control and BMI.

fundingNone.

Indexed as

BetacoronavirusPopulation SurveillanceAdultAgedAged, 80 and overCohort StudiesCoronavirus InfectionsCOVID-19Databases, FactualDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedMortality

Identifiers

PMID32798471
PMCPMC7426091
OpenAlexW3048686971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.