Evidence map›Paper›PMID 32798330›Full record

ArticleMolecular microbiology2021

Eeyarestatin 24 impairs SecYEG-dependent protein trafficking and inhibits growth of clinically relevant pathogens.

Maurice Steenhuis, Gregory M Koningstein, Julia Oswald, Tillman Pick, Sarah O'Keefe, Hans-Georg Koch, Adolfo Cavalié, Roger C Whitehead, Eileithyia Swanton, Stephen High and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. The Dynamic SecYEG Translocon.Frontiers in molecular biosciences · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Maurice SteenhuisDepartment of Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit, Amsterdam, the Netherlands.
Gregory M KoningsteinDepartment of Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit, Amsterdam, the Netherlands.
Julia OswaldInstitute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Tillman PickExperimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.
Sarah O'KeefeSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Hans-Georg KochInstitute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-5913-0334
Adolfo CavaliéExperimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.
Roger C WhiteheadSchool of Chemistry, Faculty of Science and Engineering, University of Manchester, Manchester, UK.
Eileithyia SwantonSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Stephen HighSchool of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Joen LuirinkDepartment of Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit, Amsterdam, the Netherlands.ORCID 0000-0001-8431-0804
Manchester Academic Health Science Centre · GBVrije Universiteit Amsterdam · NLSaarland University · DEUniversity of Freiburg · DEUniversity of Manchester · GB

Funding

Wellcome Trust 204957/Z/16/Z
6 · The paper itself

Abstract

Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61-dependent Ca

Indexed as

Anti-Bacterial AgentsEndoplasmic ReticulumEscherichia coliEscherichia coli ProteinsHydrazonesHydroxyureaMembrane ProteinsNitroreductasesProtein TransportSEC Translocation Channels1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyureaAnti-Bacterial AgentsEscherichia coli ProteinsHydrazonesHydroxyureaMembrane ProteinsNitroreductasesSEC Translocation Channelseeyarestatin 1Escherichia colinitrofurantoinSec61

Identifiers

PMID32798330
PMCPMC8273874
OpenAlexW3049125898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.