ArticleJournal of Ayurveda and integrative medicine
Single garlic oil modulates T cells activation and proinflammatory cytokine in mice with high fat diet.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Allium sativum Essential Oil Supplementation Reverses the Hepatic Inflammation, Genotoxicity and Apoptotic Effects in Swiss Albino Mice Intoxicated with the Lead Nitrate.Biological trace element research · 2024Article
- Article
- Medicinal Herbs: Promising Immunomodulators for the Treatment of Infectious Diseases.Molecules (Basel, Switzerland) · 2023Review
- Obesity, rather than high fat diet, exacerbates the outcome of influenza virus infection in influenza-sensitized mice.Frontiers in nutrition · 2022Article
- Roles and mechanisms of garlic and its extracts on atherosclerosis: A review.Frontiers in pharmacology · 2022Review
- Single-bulb garlic oil regulates toll-like receptors and Nrf2 cross-talk and IL-17 production in mice fed with high-fat diet.Saudi journal of biological sciences · 2021Article
- Transcriptome in Combination Proteome Unveils the Phenylpropane Pathway Involved in Garlic (Frontiers in nutrition · 2021Article
- Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high-fat, high-fructose diet mice.Journal of Ayurveda and integrative medicineArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperlipidemia triggers atherosclerosis by involving immune cells, such as T-cells. T-cells plays a role in worsening conditions during a high-fat diet (HFD).
objectiveThe research aimed to analyze the role of single garlic oil (SGO) on T-cells activation and its proinflammatory cytokine expression in HFD mice.
methodsMice were divided into six groups: ND (normal diet); HFD (high-fat diet without treatment); HFD + Simv (HFD + simvastatin 2.6 mg/kg body weight); and HFD + SGO 1-3 (high-fat diet + single garlic oil in a dose of 12.5, 25, and 50 mg/kg body weight), respectively. Treatments were orally given every day for 45 days. At the end of treatments, lymphocytes were isolated from mice spleen. The relative number of T-cells and proinflammatory cytokines were measured using flow-cytometry and analyzed using one-way ANOVA (p < 0.05).
resultOur result indicated that HFD mice had lower naive T cells (CD4+CD62L+) than normal mice (p < 0.05). SGO treatment in HFD mice increased the relative number of naïve T cells. HFD treatment increased the expression of TNF-α and IFN-γ through NF-κB expression. Furthermore, SGO treatment improved the expression of TNF-α and IFN-γ.
conclusionOur study suggests that SGO could act as a promising prospect for therapy to improve chronic inflammation in a HFD.
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