Evidence map›Paper›PMID 32797646›Full record

ArticleProtein science : a publication of the Protein Society2020

The high-resolution structure of a UDP-L-rhamnose synthase from Acanthamoeba polyphaga Mimivirus.

Nicholas J Bockhaus, Justin D Ferek, James B Thoden, Hazel M Holden

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicholas J BockhausDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA.
Justin D FerekDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA.
James B ThodenDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA.
Hazel M HoldenDepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-6214-3638
University of Wisconsin–Madison · US

Funding

Biochemical Investigations of Sugar-Modifying EnzymesR35GM134643 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HOLDEN, HAZEL M. · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM134643
6 · The paper itself

Abstract

For the field of virology, perhaps one of the most paradigm-shifting events so far in the 21st century was the identification of the giant double-stranded DNA virus that infects amoebae. Remarkably, this virus, known as Mimivirus, has a genome that encodes for nearly 1,000 proteins, some of which are involved in the biosynthesis of unusual sugars. Indeed, the virus is coated by a layer of glycosylated fibers that contain d-glucose, N-acetyl-d-glucosamine, l-rhamnose, and 4-amino-4,6-dideoxy-d-glucose. Here we describe a combined structural and enzymological investigation of the protein encoded by the open-reading frame L780, which corresponds to an l-rhamnose synthase. The structure of the L780/NADP

Indexed as

AcanthamoebaCarbohydrate EpimerasesCrystallography, X-RayMimiviridaeProtein DomainsUridine Diphosphate SugarsViral ProteinsCarbohydrate EpimerasesUDP-rhamnoseUridine Diphosphate SugarsViral Proteins6-deoxy sugarAcanthamoeba polyphaga Mimivirusgiant virusesl-rhamnoseUDP-l-rhamnose epimerase/reductaseUDP-l-rhamnose synthaseviral glycansX-ray structure

Identifiers

PMID32797646
PMCPMC7586890
OpenAlexW3049136780

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.