Evidence map›Paper›PMID 32797287›Full record

ArticleSurgery today2021

What are the important prognostic factors in gastric cancer with positive duodenal margins? A multi-institutional analysis.

Shohei Fujita, Yoko Oshima, Satoshi Yajima, Yoshinori Kikuchi, Sakae Nagaoka, Hiroharu Yamashita, Yasuyuki Seto, Muneharu Fujisaki, Norio Mitsumori, Koji Otsuka and 7 more

Abstract read
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In one paragraph

Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Shohei FujitaDepartment of Surgery, Toho University Ohashi Medical Center, 2-22-36, Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.
Yoko OshimaDivision of General and Gastroenterological Surgery, Department of Surgery (Omori), Toho University, 6-11-1, Omori-nishi, Ota-Ku, Tokyo, 143-8541, Japan.
Satoshi YajimaDivision of General and Gastroenterological Surgery, Department of Surgery (Omori), Toho University, 6-11-1, Omori-nishi, Ota-Ku, Tokyo, 143-8541, Japan.
Yoshinori KikuchiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Toho University, 6-11-1, Omori-nishi, Ota-Ku, Tokyo, 143-8541, Japan.
Sakae NagaokaDepartment of Gastroesophageal Surgery, Japanese Red Cross Medical Center, 4-1-22, Hiroo, Shibuya-Ku, Tokyo, 150-8935, Japan.
Hiroharu YamashitaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yasuyuki SetoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Muneharu FujisakiDepartment of Surgery, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Norio MitsumoriDepartment of Surgery, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Koji OtsukaDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Masahiko MurakamiDivision of Gastroenterological and General Surgery, Department of Surgery, School of Medicine, Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Hidejiro UrakamiNational Hospital Organization Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
Yoh IsobeNational Hospital Organization Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
Yutaro YoshimotoNTT Medical Center Tokyo, 5-9-22, Higashi-gotanda, Shinagawa-ku, Tokyo, 141-0022, Japan.
Hitoshi SatodateNTT Medical Center Tokyo, 5-9-22, Higashi-gotanda, Shinagawa-ku, Tokyo, 141-0022, Japan.
Yoshihisa SaidaDepartment of Surgery, Toho University Ohashi Medical Center, 2-22-36, Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.
Hideaki ShimadaDivision of General and Gastroenterological Surgery, Department of Surgery (Omori), Toho University, 6-11-1, Omori-nishi, Ota-Ku, Tokyo, 143-8541, Japan. hideaki.shimada@med.toho-u.ac.jp.
Toho University · JPJikei University School of Medicine · JPNTT Medical Center · JPShowa University · JPThe University of Tokyo · JPTokyo Medical Center · JPJapanese Red Cross Medical Center · JPToho University Ohashi Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePositive margins are reported in from 4.8 to 9.5% of all gastric cancer surgeries and they have a negative impact on the overall survival. Few cases with positive duodenal margins have been included in previous studies regarding the prognosis.

methodsThis multi-institutional retrospective study included 115 gastric cancer patients with positive duodenal margins following gastrectomy between January 2002 and December 2017. The association between clinicopathological factors and the overall survival was evaluated by univariate and multivariate analyses.

resultsThe three-year overall survival was 22% and the median survival was 13 months. A multivariate analysis found that distant metastasis, no postoperative chemotherapy, and non-Type 4 disease were significantly associated with a poor survival. Patients without distant metastasis who received postoperative chemotherapy had a 3-year overall survival of 56% and a median survival of 44 months.

conclusionThe patients who underwent post-operative chemotherapy showed a significantly better OS compared with those who did not undergo post-operative chemotherapy, regardless of the existence of distant metastasis. Postoperative chemotherapy may, therefore, improve the prognosis of surgically treated gastric cancer patients with positive duodenal margins.

Indexed as

Margins of ExcisionNeoplasm MetastasisAnalysis of VarianceAntineoplastic AgentsDuodenumFemaleHumansMalePostoperative CarePrognosisRetrospective StudiesStomach NeoplasmsSurvival RateTime FactorsAntineoplastic AgentsGastrectomyGastric cancerPositive duodenal margin

Identifiers

PMID32797287
OpenAlexW3049036928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.